Concept

Parasiticide

Publications associées (23)

Developing a Reconciled Genome-Scale Model of the Malaria Parasite Plasmodium falciparum and its Thermodynamics-based Flux Balance Analysis

Vassily Hatzimanikatis, Meriç Ataman, Stepan Tymoshenko, Dominique Soldati-Favre

Understanding the metabolism of the malaria parasites is of high priority to identify novel enzymatic drug targets and face the rise in drug resistant parasites. Based on the knowledge of metabolic functions and molecular interactions, we can reconstruct g ...

2015

A Simulation and Modeling Environment for the Analysis and Design of Charge Redistribution DACs used in SAR ADCs

Andrea Bonetti

The optimal design of SAR ADCs requires the accurate estimate of nonlinearity and parasitic effects in the feedback charge-redistribution DAC. Since the effects of both mismatch and stray capacitances depend on the specific array topology, complex calculat ...

2014

Gyrotron parasitic-effects studies using the time-dependent self-consistent monomode code TWANG

Stefano Alberti, Jean-Philippe Hogge, Trach-Minh Tran, Fengping Li

Parasitic effects have recently appeared to be a potential limiting factor for reliable operation of high-power high-frequency gyrotrons. Within the domain of validity of a self-consistent monomode model, the time-dependent code TWANG has been developed wi ...

IEEE2011

A circuit-level substrate current model for smart-power ICs

Maher Kayal, Jean-Michel Sallese, François Krummenacher, Marc Pastre, Fabrizio Lo Conte

This paper presents a new modeling methodology accounting for generation and propagation of minority carriers that can be used directly in circuit-level simulators in order to estimate coupled parasitic currents. The method is based on a new compact model ...

Institute of Electrical and Electronics Engineers2010

Medicinal properties of organometallic compounds

Paul Joseph Dyson, Claire Samantha Allardyce

Although organometallic compds. are ubiquitous in nature, synthetic organometallic compds. are generally considered to be toxic or non-compatible with biol. systems. Despite this perception the medicinal properties of organometallic compds., in particular ...

Springer2006

Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

The surge of interest in protein kinases as targets for chemotherapeutic intervention in a number of diseases such as cancer and neurodegenerative disorders has stimulated research aimed at determining whether enzymes of this class might also be considered ...

2005

Protein kinases as targets for anti-parasitic chemotherapy

Parasitic protozoa infecting humans have a staggering impact on public health, especially in the developing world. Furthermore, several protozoan species are major pathogens of domestic animals and have a considerable impact on food production. In many ins ...

2004

Solar blind (Al,Ga)N metal-semiconductor-metal devices for high performance flame detection

Nicolas Grandjean, Mauro Mosca

In this work we report on solar blind (Al,Ga)N photovoltaic metal-semiconductor-metal (MSM) detectors with a cutoff wavelength as short as similar to270 nm. (Al,Ga)N heterostructures, that allow backside illumination, were grown on sapphire substrates by b ...

Materials Research Society2003

Protein kinases as drug targets in parasitic protozoa

The importance of protein kinases in cell signaling and cell cycle control has led to detailed structural and functional studies in various eukaryotes, and hence to the synthesis of specific chemical inhibitors for managing disease. Here, the current progr ...

Elsevier2002

Production of Sm37-GAPDH, a major therapeutical target in human schistosomiasis

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in the glycolytic metabolism and the production of energy. This probably explains why GAPDH was evidenced as a major therapeutical target in several parasitic diseases; either as a vaccine ca ...

Wiley-Blackwell2000

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