Concept

Échangeur sodium-calcium

Publications associées (75)

Calcium dynamics and vasomotion in rat mesenteric arteries

Nikolaos Stergiopoulos, Jean-Jacques Meister, Jean-Louis Bény, Alexander Schuster, Mathieu Lamboley

Smooth muscle cell calcium dynamics and diameter were measured in intact pressurized rat mesenteric artery segments during vasoconstriction and vasomotion. Arteries showed a certain norepinephrine (NE) threshold (0.3-0.4 microM) for the onset of vasomotion ...

2004

Ca2+ dynamics in a population of smooth muscle cells: modeling the recruitment and synchronization

Jean-Jacques Meister, Roger Sauser, Jean-Louis Bény, Michèle Koenigsberger, Mathieu Lamboley

Many experimental studies have shown that arterial smooth muscle cells respond with cytosolic calcium rises to vasoconstrictor stimulation. A low vasoconstrictor concentration gives rise to asynchronous spikes in the calcium concentration in a few cells (a ...

Elsevier2004

Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes

Pierre Magistretti, Jean-Yves Chatton

Glutamate uptake into astrocytes and the resulting increase in intracellular Na+ (Na+(i)) have been identified as a key signal coupling excitatory neuronal activity to increased glucose utilization. Arguments based mostly on mathematical modeling led to th ...

2004

Some fundamental (and often overlooked) considerations underlying the free ion activity and biotic ligand models

Trace metal bioavailability is often evaluated on the basis of steady-state models such as the free ion activity model (FIAM) and the biotic ligand model (BLM). Some of the assumptions underlying these models were verified by examining Pb and Zn uptake by ...

2004

Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics

Pierre Magistretti, Luc Pellerin

Increasing evidence suggests that glutamate activates the generation of lactate from glucose in astrocytes; this lactate is shuttled to neurons that use it as a preferential energy source. We explore this multicellular "lactate shuttle" with a novel dual-c ...

2004

Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex

Pierre Magistretti, Pascal Steiner, Luc Pellerin, Jean-Yves Chatton, Egbert Welker

Neuron-glia interactions are essential for synaptic function, and glial glutamate (re)uptake plays a key role at glutamatergic synapses. In knockout mice, for either glial glutamate transporters, GLAST or GLT-1, a classical metabolic response to synaptic a ...

2003

Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes

Pierre Magistretti, Jean-Yves Chatton

The effects of inhibitors of the glial Na+/glutamate co-transporter on the intracellular Na+ concentration (Na+) were investigated in mouse cortical astrocytes. Na+ was monitored by fluorescence microscopy on single astrocytes using the Na+-sensi ...

2001

Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha

Johan Auwerx, Kristina Schoonjans

The isoprenoids farnesol and juvenile hormone III (JH), metabolites of the cholesterol biosynthetic pathway, have been shown to stimulate fetal epidermal development in rodents. In this study we determined whether this effect might be attributed to a direc ...

2001

Cytosolic-free calcium in smooth-muscle and endothelial cells in an intact arterial wall from rat mesenteric artery in vitro

Nikolaos Stergiopoulos, Jean-Jacques Meister, Jean-Louis Bény, Alexander Schuster

The regulation of cytosolic-free calcium concentration of smooth-muscle and endothelial cells was mainly studied on cultured cells where the cross talk between these two coupled cell types is lost. In the present study, the cytosolic-free calcium concentra ...

Elsevier2001

Simultaneous arterial calcium dynamics and diameter measurements: application to myoendothelial communication

Nikolaos Stergiopoulos, Jean-Jacques Meister, Jean-Louis Bény, Alexander Schuster

The goal of the present study was to analyze the intercellular calcium communication between smooth muscle cells (SMCs) and endothelial cells (ECs) by simultaneously monitoring artery diameter and intracellular calcium concentration in a rat mesenteric art ...

2001

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