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Reach-to-grasp tasks are composed of several actions that are more and more considered as simultaneously controlled by the central nervous system in a feedforward manner (at least for well-known activities). If this hypothesis is correct, during prehension ...
Although axonal regeneration after CNS injury is limited, partial injury is frequently accompanied by extensive functional recovery. To investigate mechanisms underlying spontaneous recovery after incomplete spinal cord injury, we administered C7 spinal co ...
In pre-hearing mice, vesicle exocytosis at cochlear inner hair cell (IHC) ribbon synapses is triggered by spontaneous Ca2+ spikes. At the onset of hearing, IHC exocytosis is then exclusively driven by graded potentials, and is characterized by higher Ca2+ ...
The neocortex makes up over 80% of the mammalian brain and is responsible for higher cognitive functions, processing of sensory inputs and orchestration of complex motor outputs. It is a 6-layered structure composed of billions of morphologically and elect ...
This paper describes how specimens of nervous tissue can be prepared for successful imaging in X-ray Micro Computed Tomography (μCT), and how this method can be used to study the integration of nervous tissue into a polymeric scaffold. The sample preparati ...
X-linked adrenoleukodystrophy (X-ALD) is the most common inherited peroxisomal disorder characterized by a progressive demyelination of the central nervous system. The marked loss of myelin and oligodendrocytes observed in the disease prompted us to evalua ...
Intensive research over the past few years has provided evidence, that stress is a potent modulator of brain function and cognition. In particular cognitive and emotional processes have been shown to be susceptible to modulation by stress. Whereas acute st ...
BACKGROUND: Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a promising approach to dissect mechanisms of pain in rodents and is a potential therapeutic strategy for the treatment of persistent pain disorders such as neuropathic pa ...
Stress is known to be a potent modulator of brain function and cognition. While prolonged and/or excessive stress generally exerts negative effects on learning and memory processes, acute stress can have differential effects on memory function depending on ...
In spite of partial success in treating Parkinson's disease by using ectopically placed grafts of dopamine-producing cells, restoration of the original neuroanatomical circuits, if possible, might work better. Previous evidence of normal anatomic projectio ...