Concept

Cancer des voies aérodigestives supérieures

Publications associées (228)

SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene amplifications, a known activating mechanism of oncogenes, target the 3q26-qter region as one of the most frequently gained/amplified genomic sites in SCC of various t ...

Public Library of Science2010

From Pyrone to Thiopyrone Ligands-Rendering Maltol-Derived Ruthenium(II)-Arene Complexes That Are Anticancer Active in Vitro

Christian Hartinger, Alexey Nazarov

Ru(II)-arene complexes with pyrone-derived ligands are rendered active against cancer cells by replacement of the coordinated O,O donor with an S,O donor. The different stabilities of these systems may explain the observed influence of the donor atoms on t ...

2009

Learning approach to analyze tumour heterogeneity in DCE-MRI data during anti-cancer treatment

Alessandro Daducci

The paper proposes a learning approach to support medical researchers in the context of in-vivo cancer imaging, and specifically in the analysis of Dynamic Contrast-Enhanced MRI (DCE-MRI) data. Tumour heterogeneity is characterized by identifying regions w ...

2009

Organometallic complexes that interconvert between trimeric and monomeric structures as a function of pH and their effect on human cancer and fibroblast cells

Paul Joseph Dyson, Rosario Scopelliti, Kay Severin, Wee Han Ang, Zacharias Immanuel Grote

Organometallic half-sandwich complexes based on ruthenium with aminomethyl-substituted 3-hydroxy-2-pyridone ligands exist in aqueous solution as monomeric O,O′-chelate complexes or trimeric metallamacrocycles depending upon the pH. We hypothesized that adm ...

2009

Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes

Paul Joseph Dyson, Zhaofu Fei, Xianfu Zhang

A targeted drug delivery system that is triggered by changes in pH based on single wall carbon nanotubes (SWCNTs), derivatized with carboxylate groups and coated with a polysaccharide material, can be loaded with the anticancer drug doxorubicin (DOX). The ...

2009

Ruthenium(II) Arene Compounds as Versatile Anticancer Agents

Anna Katherine Renfrew

Ruthenium-based compounds are an attractive alternative to clinically used platinum drugs due to several features including a wide range of accessible oxidation states, varied synthetic chemistry and typically lower general toxicities. One series of ruthen ...

2009

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells

Cathrin Brisken

Stem-like cells may be integral to the development and maintenance of human cancers. Direct proof is still lacking, mainly because of our poor understanding of the biological differences between normal and cancer stem cells (SCs). Using the ErbB2 transgeni ...

2009

Asymmetric distribution of epidermal growth factor receptor directs the fate of normal and cancer keratinocytes in vitro

Nathan Quentin Faivre

Cancer cells are unequal in a tumor mass and in established cultures. This is attributable to cancer stem cells with the unique ability to self-renew and to generate differentiating progeny. This ability is controlled at the level of asymmetric division by ...

2009

Segmentation of head and neck lymph node regions for radiotherapy planning, using active contour based atlas registration

Jean-Philippe Thiran, Meritxell Bach Cuadra, Valérie Duay, Subrahmanyam Venkata Ravi Mohana Sai Gorthi, Nawal Houhou

In this paper, we present the segmentation of the head and neck lymph node regions using a new active contour based atlas registration model. We propose to segment the lymph node regions without directly including them in the atlas registration process; in ...

2009

The "complex-in-a-complex" cations [(acac)2M.cntnd.Ru6-(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: a trojan horse for cancer cells

Paul Joseph Dyson, Anna Katherine Renfrew

The cytotoxicities of the large cationic arene-ruthenium prismatic cage [Ru6(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+ (tpt = 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine, dhbq = 2,5-dihydroxy-1,4-benzoquinolato; 16+), and its "complex-in-a-complex" derivs. [(acac)2M-1]6+ ...

2008

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