Concept
Acanthosis nigricans
Publications associées (15)
Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance
A simple predictive biomarker for fatty liver disease is required for individuals with insulin resistance. Here, we developed a supervised machine learning-based classifier for fatty liver disease using fecal 16S rDNA sequencing data. Based on the Kangbuk ...
NATURE PORTFOLIO2022Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity
Kristina Schoonjans, Alessia Perino
Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implic ...
CELL PRESS2021Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation
Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex molecular circuitry that is not yet fully elucidated. Here, we investigated geno ...
OXFORD UNIV PRESS2021Mfn2 is critical for brown adipose tissue thermogenic function
Carlos Canto Alvarez, Joanna Ratajczak, Miriam Valera Alberni
Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine-tune cellular bioenergetics. Defective mitofusin 2 (Mfn2) expression and enhanced mitochondri ...
Wiley2017