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There are two main routes for tumor spread and metastasis, the blood vasculature and the lymphatic system. A wide range of human carcinomas, including lung, colon and breast cancer, spread to distant sites via the lymphatic system. Preclinical and clinical ...
Hyperplasia associated with a loss of tissue homeostasis can induce DNA replication stress, leading to precancerous dysregulation. Epidermal {gamma}{delta} T cells reside in the primary barrier that protects against diverse environmental insults; however, ...
In this paper, we present the segmentation of the head and neck lymph node regions using a new active contour based atlas registration model. We propose to segment the lymph node regions without directly including them in the atlas registration process; in ...
We study the problem of distributed estimation, where a set of nodes are required to collectively estimate some parameter of interest from their measurements. Diffusion algorithms have been shown to achieve good performance, increased robustness and are am ...
Diffusion LMS is a distributed algorithm that allows a network of nodes to solve estimation problems in a fully distributed manner by relying solely on local interactions. The algorithm consists of two steps: a consultation step whereby each node combines ...
Most carcinomas spread to distant sites through lymphatic vessels. Several preclinical and clinical studies have shown a positive correlation between the incidence of lymph node metastasis and secretion of the lymphatic growth factor vascular endothelial g ...
Polymeric nanoparticles (NPs), prepared via coprecipitation of drugs and polymers, are promising drug delivery vehicles for treating diseases with improved efficacy and reduced toxicity. Here, we report an unprecedented strategy for preparing polylactide-c ...
This paper addresses the problem of controlling the performance of optical burst switching (OBS) networks in presence of non-stationary traffic demands. We propose a joint burst admission control and forwarding mechanism that operates in core nodes. This m ...
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CCR7 is implicated in lymph node metastasis of cancer, but its role is obscure. We report a mechanism explaining how interstitial flow caused by lymphatic drainage directs tumor cell migration by autocrine CCR7 signaling. Under static conditions, lymphatic ...
We consider the problem of distributed detection, where a set of nodes are required to decide between two hypotheses based on their measurements. In diffusion implementations, nodes communicate with their neighbors and no fusion center is needed. In previo ...