Concept

Microsatellite instability

Publications associées (12)

Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping

Background: Cancer genome sequencing enables accurate classification of tumours and tumour subtypes. However, prediction performance is still limited using exome-only sequencing and for tumour types with low somatic mutation burden such as many paediatri ...

2023

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

Filipe Amândio Brandão Sanches Vong Martins

Genomic instability enhances cancer progression by favoring clonal diversity, yet uncontrolled replicative stress can lead to mitotic catastrophe and inflammatory responses promoting immune rejection. KRAB-containing zinc finger proteins (KZFPs) are epigen ...

EPFL2023

Source-Free Open-Set Domain Adaptation for Histopathological Images via Distilling Self-Supervised Vision Transformer

Jean-Philippe Thiran, Guillaume Marc Georges Vray, Devavrat Tomar

There is a strong incentive to develop computational pathology models to i) ease the burden of tissue typology annotation from whole slide histological images; ii) transfer knowledge, e.g., tissue class separability from the withheld source domain to the d ...

2023

Innovative Techniques and Strategies for a Reliable High-Throughput Genotoxicity Assessment

Pauline Franz

Damage to DNA is a central mechanism to the initiation of carcinogenesis. As a consequence, precise DNA damage detection is essential for an effective risk assessment of xenobiotics and constitutes a powerful tool for human biomonitoring and early stage ca ...

AMER CHEMICAL SOC2020

Bioengineering Methods to Improve in vitro Adoptive Cell Therapy based on Tumor-Infiltrating Lymphocytes

François Réal Rivest

Cancer is one of the biggest medical challenges of our times, with a devastating impact across all social categories. Accordingly, considerable efforts are geared towards improving the standard of care. Among them, immunotherapy, which relies on the immune ...

EPFL2020

The consensus molecular subtypes of colorectal cancer

Douglas Hanahan, Krisztian Homicsko, Sarah Gerster, Paolo Angelino, Mauro Delorenzi, Anguraj Sadanandam, Xin Wang

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international c ...

Nature Publishing Group2015

Reconciliation of classification systems defining molecular subtypes of colorectal cancer

Douglas Hanahan, Anguraj Sadanandam, Xin Wang

Recently we published two independent studies describing novel gene expression-based classifications of colorectal cancer (CRC). Notably, each study stratified CRC into a different number of subtypes: one reported 3 subtypes, whereas the second highlighted ...

Landes Bioscience2014

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Patrick Aebischer, Bernard Schneider, Liliane Glauser, Darren Moore, Klodjan Stafa, Julien Dusonchet

Mutations in LRRK2 are one of the primary genetic causes of Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, and familial PD mutations affect both enzymatic activities. However, the signaling mechanisms regulating LRRK2 and the pathog ...

Oxford University Press2014

Uncooperative Rendezvous and Docking for MicroSats

Jean-Philippe Thiran, Herbert Shea, Volker Gass, Luzius Gregor Kronig, Muriel Richard, Federico Belloni, Oluwaseun Adelowo Araromi, Christophe Dominique Paccolat, Irina Gavrilovich

This paper proposes a solution to perform active debris removal with a cost effective microsatellite. A complex aspect of debris removal in space is the detection and positive identification of the debris, medium to close approach as well as the orbital re ...

2013

Hallmarks of Cancer: The Next Generation

Douglas Hanahan

The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proli ...

2011

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