Concept

Biogerontology

Publications associées (14)

Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years

Jacques Fellay, Christian Axel Wandall Thorball

Background Accelerated epigenetic ageing can occur in untreated HIV infection and is partially reversible with effective antiretroviral therapy (ART). We aimed to make a long-term comparison of epigenetic ageing dynamics in people with HIV during untreated ...

ELSEVIER2023

Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure

Yi Zhang, Annina Stuber, Ashish Gupta

BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...

LIPPINCOTT WILLIAMS & WILKINS2022

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Matthias Lütolf, Nathalie Brandenberg, Yoji Tabata, Nikolche Gjorevski, Mikhail Nikolaev, Nicolas Antoine Vincent Broguiere, Olga Mitrofanova, Devanjali Dutta

Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology(1-4). However, the approaches that are used at present to derive these organoids in three-dimensional matrices(5,6)r ...

NATURE PUBLISHING GROUP2020

Fatigue life prediction under realistic loading conditions

Anastasios Vassilopoulos

The accurate modeling of the fatigue behavior of composite materials under constant amplitude (CA) cyclic stress is in itself a difficult task but when loading is of variable amplitude (VA), the situation is even more complicated since an appropriate damag ...

Elsevier2019

Human audiometric thresholds do not predict specific cellular damage in the inner ear

Demetri Psaltis

Introduction: As otology enters the field of gene therapy and human studies commence, the question arises whether audiograms - the current gold standard for the evaluation of hearing function - can consistently predict cellular damage within the human inne ...

Elsevier2016

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Pierre Magistretti, Jean-René Cardinaux

Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better ...

Elsevier2016

Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis

Andrzej Sienkiewicz, Fanny Caputo

Efficient inorganic UV shields, mostly based on refracting TiO2 particles, have dramatically changed the sun exposure habits. Unfortunately, health concerns have emerged from the pro-oxidant photocatalytic effect of UV-irradiated TiO2, which mediates toxic ...

Royal Soc Chemistry2015

Multi-factorial models of a carbon fibre/epoxy composite subjected to accelerated environmental ageing

Joël Cugnoni, Enrique René Guzman Solares

Among materials being introduced in the aerospace industry, the carbon fibre reinforced plastics (CFRP) have a place of privilege because of their exceptional stiffness-to-mass ratio. However, the polymer-based matrix is vulnerable to damages by environmen ...

Elsevier2014

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Martin Kussmann, Sebastiano Collino, Fiona Beguelin

As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metab ...

Impact Journals Llc2014

Identification of genetic determinants and pharmacological modulators of mitochondrial function

Pénélope Andreux

Increased life expectancy goes hand in hand with a higher incidence of age-related diseases that affect the nervous and metabolic systems, such as type 2 diabetes, cancer, Parkinson’s and Alzheimer’s disease. These complex diseases are a product of the com ...

EPFL2013

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