Concept
Composé tricyclique
Publications associées (9)
Combinatorial targeting of angiogenesis with inducers of autophagy in the treatment of glioblastoma multiforme
Malignant gliomas represent 80% of tumors developing in the central nervous system, with 50% being glioblastomas (GBM), the most aggressive form of the disease. The benefit from current therapies is very limited, the overall 5-year survival rate of patient ...
EPFL2018The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression
Pierre Magistretti, Jean-René Cardinaux
Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better ...
Elsevier2016Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression
Pierre Magistretti, Jean-René Cardinaux
Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood di ...
Nature Publishing Group2016Synthetic Study towards Strictamine: The Oxidative Coupling Approach
Qian Wang, Jieping Zhu, Weiwu Ren, Nicholas David Charles Tappin
A synthetic approach featuring a key intramolecular oxidative coupling of a dianion for the formation of the C7–C16 bond was exploited aiming at the synthesis of strictamine. Treatment of substituted tetrahydrocarboline with LHMDS at –78 °C followed by iod ...
Georg Thieme Verlag Kg2013Three-component synthesis of polysubstituted 6-azaindolines and its tricyclic derivatives
By simply heating a toluene soln. of isocyanoacetamide, amine, and aldehyde, a clean three-component reaction occurred to provide the 6-azaindolines and pyrrolidinone-fused 6-azaindolines. E.g., heating a mixt. of morpholine, heptanal, and isocyanoacetamid ...
2005