Publications associées à Centriole

Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number

Kai Johnsson, Pierre Gönczy, Michele Graciotti, Zhou Fang

Centrioles are microtubule-based organelles found in most eukaryotic cells and that are critical for the formation of cilia and flagella, as well as of centrosomes in animal cells. The number of centrioles must be strictly regulated in proliferating cells ...

Wiley-Blackwell2016

Isolation, cryotomography, and three-dimensional reconstruction of centrioles

Pierre Gönczy, Paul Guichard, Virginie Hamel, Aitana Neves da Silva

Centrioles and basal bodies (referred to hereafter as centrioles for simplicity) are microtubule-based cylindrical organelles that are typically ∼450-nm long and ∼250nm in diameter. The centriole is composed of three distinct regions: the distal part chara ...

Elsevier2015

Isolation, cryotomography, and three-dimensional reconstruction of centrioles

Pierre Gönczy, Paul Guichard, Virginie Hamel, Aitana Neves da Silva

Elsevier2015

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

Pierre Gönczy, Georgios Hatzopoulos, Nicola Jane Dynes, Sheng Kai Pong

Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic evol ...

2015

Purification of centrosomes from mammalian cell lines

Paul Guichard

Centrosomes act as the main microtubule-organizing centre of animal cells and play critical roles in the cell, such as mitotic spindle organization, cell polarity, and motility. They are composed of two barrel-shaped structures, the centrioles, surrounded ...

Elsevier Academic Press Inc2015

Quantitative Analysis and Modeling Probe Polarity Establishment in C. elegans Embryos

Pierre Gönczy, Felix Naef, Coralie Busso, Simon Blanchoud

Cell polarity underlies many aspects of metazoan development and homeostasis, and relies notably on a set of PAR proteins located at the cell cortex. How these proteins interact in space and time remains incompletely understood. We performed a quantitative ...

Cell Press2015

Multi-dimensional imaging and phenotyping of C. elegans embryos via an automated microfluidic device

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Alexis Pierre Henri Marette, Virginija Jovaisaite, Shreya Narasimhan

We introduce a microfluidic platform for automated on-chip worm culture, creation of synchronized embryo microarrays, and long-term parallel live imaging of Caenorhabditis elegans embryos. Our device allows studying well-defined embryo populations at unpre ...

2015

Polarity-Dependent Asymmetric Distribution and MEX-5/6-Mediated Translational Activation of the Era-1 mRNA in C. elegans Embryos

Pierre Gönczy

The early C. elegans embryo is an attractive model system to investigate fundamental developmental processes. With the exception of mex-3 mRNA, maternally contributed mRNAs are thought to be distributed uniformly in the one-cell embryo. Here, we report and ...

Public Library of Science2015

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Centriole

Mechanisms of centrosome separation in C. elegans

Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

Isolation, cryotomography, and three-dimensional reconstruction of centrioles

Isolation, cryotomography, and three-dimensional reconstruction of centrioles

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

Purification of centrosomes from mammalian cell lines

Quantitative Analysis and Modeling Probe Polarity Establishment in C. elegans Embryos

Multi-dimensional imaging and phenotyping of C. elegans embryos via an automated microfluidic device

Polarity-Dependent Asymmetric Distribution and MEX-5/6-Mediated Translational Activation of the Era-1 mRNA in C. elegans Embryos

Graph Chatbot

Chattez avec Graph Search

Purification of centrosomes from mammalian cell lines

Quantitative Analysis and Modeling Probe Polarity Establishment in C. elegans Embryos

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

Mechanisms of centrosome separation in C. elegans

Isolation, cryotomography, and three-dimensional reconstruction of centrioles

Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number

Isolation, cryotomography, and three-dimensional reconstruction of centrioles

Polarity-Dependent Asymmetric Distribution and MEX-5/6-Mediated Translational Activation of the Era-1 mRNA in C. elegans Embryos

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

Multi-dimensional imaging and phenotyping of C. elegans embryos via an automated microfluidic device