Concept
Allogreffe
Publications associées (33)
Autologous and Allogeneic Cytotherapies for Large Knee (Osteo)Chondral Defects: Manufacturing Process Benchmarking and Parallel Functional Qualification
Corinne Scaletta, Sandra Jaccoud, Philippe Abdel Sayed, Nathalie Hirt-Burri, Robin Martin, Salim Elias Darwiche, Cédric Peneveyre, Annick Jeannerat, Alexis Laurent
Cytotherapies are often necessary for the management of symptomatic large knee (osteo)-chondral defects. While autologous chondrocyte implantation (ACI) has been clinically used for 30 years, allogeneic cells (clinical-grade FE002 primary chondroprogenitor ...
Basel2023Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates
Freddy Radtke, Ute Koch, Catherine Michelle Hoffman
Notch signaling promotes T cell pathogenicity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) in mice, with a dominant role for the Delta-like Notch ligand DLL4. To assess whether Notch's effects are evol ...
AMER ASSOC ADVANCEMENT SCIENCE2023Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes
Sandrine Gerber, Qixing Zhang, Yi Wang, Léo Bühler
Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D). Currently, clinical islet transplantation is limited by allo - and autoimmunity that may cause partial or complete loss of islet function within a short period of tim ...
2022Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters.
Sandrine Gerber, Luca Szabó, Léo Bühler
Neonatal and juvenile porcine islet cell clusters (ICC) present an unlimited source for islet xenotransplantation to treat type 1 diabetes patients. We isolated ICC from pancreata of 14 days old juvenile piglets and characterized their maturation by immuno ...
2021Efficient decellularization of equine tendon with preserved biomechanical properties and cytocompatibility for human tendon surgery indications
Dominique Pioletti, Nathalie Hirt-Burri, Jens Antons, Cédric Peneveyre, Anthony Grognuz, Pierre-Arnaud Aeberhard
Chronic and acute tendon injuries are frequent afflictions, for which treatment is often long and unsatisfactory. When facing extended injuries, matrices and scaffolds with sufficient biomechanical properties are required for surgical repair and could addi ...
2019Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation
Berna Ayse Özkale Edelmann, Christina Myra Tringides
Mesenchymal stem cell (MSC) therapies demonstrate particular promise in ameliorating diseases of immune dysregulation but are hampered by short in vivo cell persistence and inconsistencies in phenotype. Here, we demonstrate that biomaterial encapsulation i ...
NATL ACAD SCIENCES2019Modeling hematopoietic stem cell dynamics in bioengineered niches
Bone marrow transplantation is a well-established medical procedure for the treatment of various hematologic diseases. However, the relatively low number of hematopoietic stem cells (HSCs) that can be harvested, especially from umbilical cord blood, limits ...
EPFL2019Anti-fibrotic effect of ketoprofen-grafted alginate microcapsules in the transplantation of insulin producing cells
Sandrine Gerber, François Rémi Pierre Noverraz, Daniel Ortiz Trujillo, Luca Szabó, Léo Bühler
The controlled release of small molecular modulators of the immune response from hydrogel microspheres (MS) used for cell immobilization is an attractive approach to reduce pericapsular fibrotic overgrowth (PFO) after transplantation. Ketoprofen is a well- ...
2018Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands
Alloimmune T cell responses induce graft-versus-host disease (GVHD), a serious complication of allogeneic bone marrow transplantation (allo-BMT). Although Notch signaling mediated by Delta-like 1/4 (DLL1/4) Notch ligands has emerged as a major regulator of ...
Amer Soc Clinical Investigation Inc2017Scaffold requirements for periodontal regeneration with enamel matrix derivative proteins
John Christopher Plummer, Laurent Mirko Dejace, Matteo Gregorio Modesto Marascio, Peter Fischer, Alessandra Apicella
Periodontitis affects the attachment of natural teeth, and infection or inflammation associated with periodontitis may affect peri-implant tissues. Enamel matrix derivative (EMD) proteins provide stimulation for self-regeneration of the damaged tissue when ...
Elsevier Science Bv2017