Concept
Background selection
Publications associées (39)
Euclid preparation XXXVII. Galaxy colour selections with Euclid and ground photometry for cluster weak-lensing analyses
Frédéric Courbin, Georges Meylan, Gianluca Castignani, Maurizio Martinelli, Matthias Wiesmann, Yi Wang, Richard Massey, Fabio Finelli, Marcello Farina
Aims. We derived galaxy colour selections from Euclid and ground-based photometry, aiming to accurately define background galaxy samples in cluster weak-lensing analyses. These selections have been implemented in the Euclid data analysis pipelines for gala ...
Edp Sciences S A2024Frequent asymmetric migrations suppress natural selection in spatially structured populations
Anne-Florence Raphaëlle Bitbol, Alia Abbara
Natural microbial populations often have complex spatial structures. This can impact their evolution, in particular the ability of mutants to take over. While mutant fixation probabilities are known to be unaffected by sufficiently symmetric structures, ev ...
Oxford2023Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity
Anne-Florence Raphaëlle Bitbol
The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that i ...
National Academy of Sciences2022Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer's Disease
The search for an understanding of the causal elements that lead to neurodegenerative diseases has motivated researchers for decades. Today, Alzheimer's disease is the most prevalent form of dementia and affects approximately fifty million people worldwide ...
EPFL2022Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores
Jacques Fellay, Christian Axel Wandall Thorball
Background In people with human immunodeficiency virus (PWH), it is unknown whether genetic background associates with rapid progression of kidney dysfunction (ie, estimated glomerular filtration rate [eGFR] decrease of >5mL/min/1.73m(2) per year for >= 3 ...
OXFORD UNIV PRESS INC2021Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in mouse
Overweight and obesity are increasingly common public health issues worldwide, leading to a wide range of diseases from metabolic syndrome to steatohepatitis and cardiovascular diseases. While the increase in the prevalence of obesity is partly attributabl ...
EPFL2021Contribution of Genetic Background and Data Collection on Adverse Events of Anti-human Immunodeficiency Virus (HIV) Drugs (D:A:D) Clinical Risk Score to Chronic Kidney Disease in Swiss HIV-infected Persons With Normal Baseline Estimated Glomerular Filtration Rate
Jacques Fellay, Christian Axel Wandall Thorball
Background. In human immunodeficiency virus (HIV), the relative contribution of genetic background, clinical risk factors, and antiretrovirals to chronic kidney disease (CKD) is unknown. Methods. We applied a case-control design and performed genome-wide g ...
OXFORD UNIV PRESS INC2020Limits on amplifiers of natural selection under death-Birth updating
The fixation probability of a single mutant invading a population of residents is among the most widely-studied quantities in evolutionary dynamics. Amplifiers of natural selection are population structures that increase the fixation probability of advanta ...
PUBLIC LIBRARY SCIENCE2020Population structure determines the tradeoff between fixation probability and fixation time
The rate of biological evolution depends on the fixation probability and on the fixation time of new mutants. Intensive research has focused on identifying population structures that augment the fixation probability of advantageous mutants. But these ampli ...
Springer2019Likelihood-free Inference of Population Genetic Parameters from Time-Sampled Genetic Data
This thesis consists of five papers published in peer-reviewed journals, two of which focus on method development of time-serial inference, represented by publications in methodology journals, and three others that describe collaborative data applications ...
EPFL2018