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Maladie

Publications associées (213)

Transgenic Model Systems Have Revolutionized the Study of Disease

Alexandre Gauthier Aurèle Mayran, Christopher Chase Bolt

The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected most of the world in a profound way. As an indirect consequence, the general public has been put into direct contact with the research process, almost ...

MARY ANN LIEBERT, INC2021

Hybrid hydrogels for load-bearing implants

Céline Samira Wyss

Load-bearing tissues such as articular cartilage or meniscus are not infallible. They might fail due to trauma, over-solicitations, or diseases, which could subsequently alter the mobility of the patient. Repairing these damaged tissues in a minimally inva ...

EPFL2021

Neurodegeneration Structural strains of tau protein classify diseases

Henning Paul-Julius Stahlberg

In diseases called tauopathies, misfolded tau proteins form aggregates called fibrils. Fibrils from nine different tauopathies show that tau misfolds in many ways, enabling the diseases to be classified according to fibril structure. ...

2021

Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?

Hilal Lashuel, Grégoire Millet, Johannes Burtscher, Muhammed Muazzam Kamil Syed

Several lines of research point to a key role of low oxygen supply (hypoxia) in Parkinson's disease pathogenesis. Although severe hypoxia is detrimental for the brain, physiological adaptations to mild hypoxia are neuroprotective. Herein we discuss, how ne ...

WILEY2021

Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader

Guido Van Mierlo

The human gut microbiota plays a central role in intestinal health and disease. Yet, many of its bacterial constituents are functionally still largely unexplored. A crucial prerequisite for bacterial survival and proliferation is the creation and/or exploi ...

TAYLOR & FRANCIS INC2021

The representativeness of ground-based air quality monitoring stations: observation and recommendation from Indian cities

Athanasios Nenes, Satoshi Takahama, Arindam Roy

It is well established that the high level of particulate matter is a leading cause of premature mortality and disease worldwide and especially in South Asia (Global Burden of Disease Study, 2019). The ground-based air quality (AQ) monitoring stations are ...

2021

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

Dylan Lawless, Beibei Wu

CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor stimulation and activation of the Ca2+-NFAT and JNK-AP1 pathways. CRACR2A has been linked to human d ...

eLIFE SCIENCES PUBL LTD2021

Structural strains of misfolded tau protein define different diseases

Henning Paul-Julius Stahlberg

2021

Multidisciplinary Approach to Treat Erectile Dysfunction

Mikaël Nils Sturny

Erectile dysfunction (ED) is a widespread disease affecting approximately 20% of men. With a rising incidence due to the global ageing of the world population, it is estimated that over 322 million patients will be affected in 2025. While not being a lifet ...

EPFL2020

Interactions between Personality, Depression, Anxiety and Cognition to Understand Early Stage of Alzheimer's Disease

Valérie Rita Madeleine Zufferey

The multifaceted nature of Alzheimer's disease (AD) and Mild cognitive impairment (MCI) can lead to wide inter-individual differences in disease manifestation in terms of brain pathology and cognition. The lack of understanding of phenotypic diversity in A ...

BENTHAM SCIENCE PUBL LTD2020

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