Concept

Dendrite (biologie)

Publications associées (132)

Network-timing-dependent plasticity

Henry Markram, Eilif Benjamin Muller, Daniel Keller, Vincent Delattre

Bursts of activity in networks of neurons are thought to convey salient information and drive synaptic plasticity. Here we report that network bursts also exert a profound effect on Spike-Timing-Dependent Plasticity (STDP). In acute slices of juvenile rat ...

2015

Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron

Henry Markram, Srikanth Ramaswamy

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied neuron types in the mammalian neocortex and has become a benchmark for understanding information processing in excitatory neurons. By virtue of having the widest local ...

Frontiers Research Foundation2015

Statistical structure of neural spiking under non-Poissonian or other non-white stimulation

Tilo Schwalger

Nerve cells in the brain generate sequences of action potentials with a complex statistics. Theoretical attempts to understand this statistics were largely limited to the case of a temporally uncorrelated input (Poissonian shot noise) from the neurons in t ...

Springer2015

NeuroMorph: A Toolset for the Morphometric Analysis and Visualization of 3D Models Derived from Electron Microscopy Image Stacks

Pascal Fua, Graham Knott, Corrado Cali, Biagio Nigro, Anne Alison Jorstad, Marta Wawrzyniak

Serial electron microscopy imaging is crucial for exploring the structure of cells and tissues. The development of block face scanning electron microscopy methods and their ability to capture large image stacks, some with near isotropic voxels, is proving ...

Humana Press2015

RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse

Ralf Schneggenburger, Yunyun Han, Zsolt Norbert Babai

The localization and density of voltage-gated Ca2+ channels at active zones are essential for the amount and kinetics of transmitter release at synapses. RIM proteins are scaffolding proteins at the active zone that bind to several other presynaptic protei ...

American Physiological Society2015

Dendritic Excitability and Gain Control in Recurrent Cortical Microcircuits

Idan Segev

Layer 5 thick tufted pyramidal cells (TTCs) in the neocortex are particularly electrically complex, owing to their highly excitable dendrites. The interplay between dendritic nonlinearities and recurrent cortical microcircuit activity in shaping network re ...

Oxford University Press2014

Spike-timing prediction in cortical neurons with active dendrites

Wulfram Gerstner, Richard Naud, Brice Bathellier

A complete single-neuron model must correctly reproduce the firing of spikes and bursts. We present a study of a simplified model of deep pyramidal cells of the cortex with active dendrites. We hypothesized that we can model the soma and its apical dendrit ...

Frontiers Research Foundation2014

The Relationship between PSD-95 Clustering and Spine Stability In Vivo

Graham Knott, Bohumil Maco

The appearance and disappearance of dendritic spines, accompanied by synapse formation and elimination may underlie the experience-dependent reorganization of cortical circuits. The exact temporal relationship between spine and synapse formation in vivo re ...

Soc Neuroscience2014

Learning improvement after PI3K activation correlates with de novo formation of functional small spines

Maria del Carmen Sandi Perez

PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide ...

2014

Dendritic tree extraction from noisy maximum intensity projection images in C-elegans

Pascal Fua, Raphael Sznitman, Josué Sznitman

Background: Maximum Intensity Projections (MIP) of neuronal dendritic trees obtained from confocal microscopy are frequently used to study the relationship between tree morphology and mechanosensory function in the model organism C. elegans. Extracting den ...

Biomed Central Ltd2014

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