Concept

Ganglion lymphatique

Publications associées (191)

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells

Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its cellular source in the periphery remains poorly defined. Here we report a critical function for lymph node access in T cell homeostasis and identify T zone fibr ...

Nature Publishing Group2007

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Antigen targeting and adjuvancy schemes that respectively facilitate delivery of antigen to dendritic cells and elicit their activation have been explored in vaccine development. Here we investigate whether nanoparticles can be used as a vaccine platform b ...

Nature Publishing Group2007

Regulation of lymphatic capillary regeneration by interstitial flow in skin

Melody Swartz, Joseph Rutkowski

Decreased interstitial flow (IF) in secondary lymphedema is coincident with poor physiological lymphatic regeneration. However, both the existence and direction of causality between IF and lymphangiogenesis remain unclear. This is primarily because the rol ...

2007

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone

Stewart Cole

Mycolactone is a polyketide toxin produced by Mycobacterium ulcerans (Mu), the causative agent of the skin disease Buruli ulcer (BU). Surprisingly, infected tissues lack inflammatory infiltrates. Structural similarities between mycolactone and immunosuppre ...

2007

Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis

Melody Swartz, Joseph Rutkowski, Miriella Carmela Pasquier

Activation of vascular endothelial growth factor ( VEGF) receptor-3 (VEGFR-3) by VEGF-C initiates lymphangiogenesis by promoting lymphatic proliferation and migration. However, it is unclear whether VEGFR-3 signaling is required beyond these initial stages ...

Federation of American Society of Experimental Biology2007

Eviction of Misbehaving and Faulty Nodes in Vehicular Networks

Jean-Pierre Hubaux, Imad Aad, Panagiotis Papadimitratos, Maxime Raya, Daniel Jungels

Vehicular Networks (VNs) are emerging, among civilian applications, as a convincing instantiation of the mobile networking technology. However, security is a critical factor and a significant challenge to be met. Misbehaving or faulty network nodes have to ...

2007

In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy, Annemie Rehor

Delivery of biodegradable nanoparticles to antigen-presenting cells (APCs), specifically dendritic cells (DCs), has potential for immunotherapy. This study investigates the delivery of 20, 45, and 100nm diameter poly(ethylene glycol)-stabilized poly(propyl ...

2006

Tumor-infiltrating dendritic cells are potent antigen-presenting cells able to activate T cells and mediate tumor rejection

Friedrich Beermann

Dendritic cells (DC) are potent inducers of immune responses. DC have been shown to infiltrate tumors, but very little is known about the functional status of these naturally occurring tumor-infiltrating DC (TIDC). In this study, the status and function of ...

2006

Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9

Melody Swartz, Joseph Rutkowski

Disturbances in the microcirculation can lead to secondary lymphedema, a common pathological condition that, despite its frequency, still lacks a cure. Lymphedema is clinically well described, but while the genetic underpinnings that cause lymphatic malfor ...

2006

Ad-hoc wireless sensor networks for exploration of solar-system bodies

Herbert Shea

In this work, we evaluate the exploration of the solar system by ad-hoc wireless sensor networks (WSN), i.e. networks where all nodes (either moving or stationary) can both provide and relay data. The two aspects of self-organization and localization are t ...

2006

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search