Concept

Cell fate determination

Publications associées (85)

RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression

Polycomb group (PcG) proteins play a pivotal role in silencing developmental genes and help to maintain various stem and precursor cells and regulate their differentiation. PcG factors also regulate dynamic and complex regional specification, particularly ...

Company Of Biologists Ltd2016

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control

Gioele La Manno

Despite the variety of physiological and target-related functions, little is known regarding the cellular complexity in the sympathetic ganglion. We explored the heterogeneity of mouse stellate and thoracic ganglia and found an unexpected variety of cell t ...

2016

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity

Paloma Ordonez Moran

Polycomb repressive complexes (PRCs) are among the most important gatekeepers of establishing and maintaining cell identity in metazoans. PRC1, which plays a dominant role in this context, executes its functions via multiple subcomplexes, which all contrib ...

Cell Press2016

Cell-Instructive Microgels with Tailor-Made Physicochemical Properties

Matthias Lütolf, Simone Allazetta, Laura Kolb, Samantha Zerbib

A microfluidic in vitro cell encapsulation platform to systematically test the effects of microenvironmental parameters on cell fate in 3D is developed. Multiple cell types including fibroblasts, embryonic stem cells, and cancer cells are incorporated in e ...

Wiley-V C H Verlag Gmbh2015

Transcription factors (TFs) are key regulators of cell fate. The estimated 755 genes that encode DNA binding domain-containing proteins comprise similar to 5% of all Drosophila genes. However, the majority has remained uncharacterized so far due to the lac ...

Cold Spring Harbor Laboratory Press2015

Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos

Pierre Gönczy

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps during earlydevelopment. In this review, we discuss processes that set up the embryonic axes, with an emphasis onpolarity establishment and asymmetric division. W ...

WormBook2014

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

Sebastian Martin Waszak

A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the oppos ...

Cell Press2014

3D niche microarrays for systems-level analyses of cell fate

Matthias Lütolf, Adrian Ranga, Samy Gobaa, Katarzyna Mosiewicz, Andrea Negro, Yuya Okawa

The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D) microenvironment and involves a dynamic interplay between biochemical and mechanical signals provided by the extracellular matrix (ECM), cell–cell interactions and solub ...

Nature Publishing Group2014

Generation of dispersed presomitic mesoderm cell cultures for imaging of the zebrafish segmentation clock in single cells

Andrew Charles Oates, Daniele Soroldoni

Segmentation is a periodic and sequential morphogenetic process in vertebrates. This rhythmic formation of blocks of tissue called somites along the body axis is evidence of a genetic oscillator patterning the developing embryo. In zebrafish, the intracell ...

2014

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Mammalian cell behavior is strongly influenced by physical and chemical cues originating from the extracellular matrix (ECM). In vivo, ECM signals are displayed in a spatiotemporally complex fashion, often composed as gradients and in concentration profile ...

Royal Soc Chemistry2014

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