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Publications associées (27)
Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation
Christian Heinis, Xinjian Ji, Edward Jeffrey Will, Anne Sofie Luise Zarda, Alessandro Angelini, Alexander Lund Nielsen, Manuel Leonardo Merz, Mischa Schüttel, Ganesh Kumar Mothukuri, Zsolt Bognár
Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for the synthesis and screening of large combinator ...
Wiley-V C H Verlag Gmbh2024Generating macrocyclic inhibitors of protein-protein interactions
Protein-protein interactions (PPIs) play important roles in many diseases and their modulation is an attractive strategy for developing new therapeutics. However, the relatively large and often flat binding surfaces of PPIs makes the development of inhibit ...
EPFL2022Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides
Christian Heinis, Peter Matei Frisius Pânzar, Alexander Lund Nielsen, Manuel Leonardo Merz, Ganesh Kumar Mothukuri, Zsolt Bognár
Thiol groups are suitable handles for site-selectively modifying, immobilizing or cyclizing individual peptides or entire peptide libraries. A limiting step in producing the thiol-functionalized peptides is the chromatographic purification, which is partic ...
ROYAL SOC CHEMISTRY2022Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands
Gerardo Turcatti, Julien Bortoli Chapalay, Xudong Kong, Van Manh Pham, Patrick Andreas Gonschorek, Sangram Shivdas Kale, Milan Bergeron-Brlek, João Miguel Franco Machado
Macrocyclic compounds are an attractive modality for drug development, but the limited availability of large, structurally diverse macrocyclic libraries hampers the discovery of leads. Here, we describe the discovery of efficient macrocyclization reactions ...
2019Rational design of a high-throughput droplet sorter
Tobias Schneider, Simon Sebastian Schütz
The high-throughput selection of individual droplets is an essential function in droplet-based microfluidics. Fluorescence-activated droplet sorting is achieved using electric fields triggered at rates up to 30 kHz, providing the ultra-high throughput rele ...
2019Integrated microfluidic tools for the characterization of protein/DNA interactions in vitro and in vivo
The specific interaction between DNA and proteins constitutes one of the crucial elements in the regulation of gene expression. This thesis focuses on the development and optimization of two microfluidic-based technologies called SMiLE-seq and FloChIP that ...
EPFL2019New Techniques for the Digitization of Art Historical Photographic Archives - the Case of the Cini Foundation in Venice
Frédéric Kaplan, Isabella Di Lenardo, Benoît Laurent Auguste Seguin
Numerous libraries and museums hold large art historical photographic collections, numbering millions of images. Because of their non-standard format, these collections pose special challenges for digitization. This paper address these difficulties by prop ...
2018Semisynthetic Biosensors for the Quantification of Nicotinamide Adenine Dinucleotides in Live Cells
Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are crucial redox cofactors regulating energy metabolism, reductive biosynthesis and the antioxidant defense system. Besides their role as redox cofactors, NAD(P ...
EPFL2018ProteusTM: Abstraction Meets Performance in Transactional Memory
Rachid Guerraoui, Anne-Marie Kermarrec, Diego Didona
The Transactional Memory (TM) paradigm promises to greatly simplify the development of concurrent applications. This led, over the years, to the creation of a plethora of TM implementations delivering wide ranges of performance across workloads. Yet, no un ...
Assoc Computing Machinery2016