Concept

Réparation de l'ADN

Publications associées (615)

Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs

Paolo De Los Rios, Pierre Goloubinoff, Vishal Sood, Andrija Finka

Classic semiquantitative proteomic methods have shown that all organisms respond to a mild heat shock by an apparent massive accumulation of a small set of proteins, named heat-shock proteins (HSPs) and a concomitant slowing down in the synthesis of the ot ...

Springer2015

The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer

Melanie Blokesch, Lisa Christina Metzger, Tiziana Scrignari

Natural competence for transformation is a common mode of horizontal gene transfer and contributes to bacterial evolution. Transformation occurs through the uptake of external DNA and its integration into the genome. Here, we show that the type VI secretio ...

Amer Assoc Advancement Science2015

Impedance sensing of DNA immobilization and hybridization by microfabricated alumina nanopore membranes

Jürgen Brugger, Philippe Renaud, Songmei Wu, Robert Meissner, Mojtaba Taghipoor

In this work we demonstrate microfabricated thin alumina nanopore membranes as a platform for impedance sensing of DNA immobilization and hybridization. We develop a wafer-scale fabrication of free-standing alumina nanopore membranes with well controlled t ...

Elsevier Science Sa2015

Ligand-Centred Fluorescence and Electronic Relaxation Cascade at Vibrational Time Scales in Transition-Metal Complexes

Majed Chergui, Enrico Pomarico, Mahsa Silatani

Using femtosecond-resolved photoluminescence up-conversion, we report the observation of the fluorescence of the high-lying ligand-centered (LC) electronic state upon 266 nm excitation of an iridium complex, Ir(ppy)(3), with a lifetime of 70 +/- 10 fs. It ...

Amer Chemical Soc2015

Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity

Paul Joseph Dyson, Ursula Röthlisberger, Wee Han Ang, Alexey Nazarov, Pablo Campomanes Ramos, Catherine Marie Amélie Clavel, Michael Groessl

Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity and clearance properties. Nonetheless, their molecular targeting and mechanism of action are poorly ...

2014

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

Andrea Ablasser

Cytosolic detection of DNA is crucial for the initiation of antiviral immunity but can also cause autoimmunity in the context of endogenous nucleic acids being sensed. Mutations in the human 3' repair exonuclease 1 (TREX1) have been linked to the type I IF ...

2014

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

Joachim Lingner, Antonio Porro, Sascha Feuerhahn

Telomeres protect chromosome ends from being recognized as sites of DNA damage. Upon telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding factor 2 (TRF2), telomeres elicit a DNA-damage response leading to cellular senescenc ...

Elsevier2014

Visualizing phosphodiester-bond hydrolysis by an endonuclease

The enzymatic hydrolysis of DNA phosphodiester bonds has been widely studied, but the chemical reaction has not yet been observed. Here we follow the generation of a DNA double-strand break (DSB) by the Desulfurococcus mobilis homing endonuclease I-DmoI, t ...

2014

DNA Transport across the Outer and Inner Membranes of Naturally Transformable Vibrio cholerae Is Spatially but Not Temporally Coupled

Melanie Blokesch, Patrick Martin Seitz

The physiological state of natural competence for transformation allows certain bacteria to take up free DNA from the environment and to recombine such newly acquired DNA into their chromosomes. However, even though conserved components that are required t ...

American Society for Microbiology2014

Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles

Therapeutic engineered nanoparticles (NPs), including ultrasmall superparamagnetic iron oxide (USPIO) NPs, may accumulate in the lower digestive tract following ingestion or injection. In order to evaluate the reaction of human colon cells to USPIO NPs, th ...

Dove Medical Press Ltd2014

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