Publications associées à Complement component 1q

Nanoscale organization of the endogenous ASC speck

The NLRP3 inflammasome is a central component of the innate immune system. Its activation leads to for-mation of the ASC speck, a supramolecular assembly of the inflammasome adaptor protein ASC. Different models, based on ASC overexpression, have been prop ...

Cell Press2023

CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection

Ludovic Pierre Gustave Keiser, Laura Desban

The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether and how sensory cells in the central nervous system (CNS) become activated during bacteri ...

CELL PRESS2023

Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fc gamma Receptor I

Arne Seitz, Romain Guiet, Duncan-Bruce Sutherland, Nicola Harris, Benjamin John Marsland, Beatrice Volpe, Julia Esser-von Bieren, Manuel Kulagin

Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helmin ...

American Association of Immunologists ; Oxford University Press2015

Arranged Sevenfold: Structural Insights into the C-Terminal Oligomerization Domain of Human C4b-Binding Protein

Matteo Dal Peraro, Matteo Thomas Degiacomi

The complement system as a major part of innate immunity is the first line of defense against invading microorganisms. Orchestrated by more than 60 proteins, its major task is to discriminate between host cells and pathogens and to initiate immune response ...

Academic Press Ltd- Elsevier Science Ltd2013

Role and regulation of the melanization reaction in Drosophila immune response

Olivier Binggeli

In arthropods, the melanization reaction consists in the rapid synthesis of melanin at the site of infection and injury. A key enzyme in the melanization process is phenoloxidase (PO), which catalyzes the oxidation of phenols to quinones that subsequently ...

EPFL2013

Biophysical Regulation of Lymphatic Vessel Function : Flow as a Mediator of Immune Cell and Fluid Transport

Dimana Miteva

Lymphatic capillaries collect interstitial fluid and dendritic cells from the periphery and deliver them to the lymph nodes for immune surveillance and tolerance maintenance. Upon injury and inflammation, lymphatic drainage can increase rapidly, and thus t ...

EPFL2010

Exploiting immunofunctional nanoparticles as vaccines and synthetic pathogens

Sai Reddy

The emergence of recombinant DNA technology has shifted research towards developing subunit vaccines, which use protein or peptide antigens instead of live/attenuated pathogens. Recent research has also shown that the best way to get sustained immunity is ...

EPFL2008

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Antigen targeting and adjuvancy schemes that respectively facilitate delivery of antigen to dendritic cells and elicit their activation have been explored in vaccine development. Here we investigate whether nanoparticles can be used as a vaccine platform b ...

Nature Publishing Group2007