Publications associées à Acide désoxycholique

Molecular physiology of bile acid signaling in health, disease, and aging

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Laura Alejandra Velazquez Villegas

Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut microbio ...

2021

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Kristina Schoonjans

Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are modulato ...

NATURE PUBLISHING GROUP2020

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Kristina Schoonjans, Giovanni Sorrentino

Glucagon-like peptide 1 (GLP-1) mimetics are effective drugs for treatment of type 2 diabetes, and there is consequently extensive interest in increasing endogenous GLP-1 secretion and L-cell abundance. Here we identify G-protein-coupled bile acid receptor ...

AMER DIABETES ASSOC2020

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Kristina Schoonjans, Alessia Perino, Maroun Bou Sleiman, Giovanni Sorrentino, Ece Yildiz, Gaby El Alam

BACKGROUND & AIMS: Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nu ...

2020

Bioavailability of steroid hormones sorbed on microplastics for aquatic organisms through biological fluids

Florian Frédéric Vincent Breider, Thibault Béranger Masset, Cécilia Laetitia Carla Siri, Yang Liu

Many studies have reported that hydrophobic organic contaminants have the ability to sorb on microplastics in aquatic ecosystem via different mechanisms of sorption. However, a lack of studies investigating desorption of such contaminants in organism fluid ...

2020

First Report of Chenodeoxycholic Acid-Substituted Dyes Improving the Dye Monolayer Quality in Dye-Sensitized Solar Cells

Ulf Anders Hagfeldt

Chenodeoxycholic acid (CDCA) is the most used antiaggregation additive in dye-sensitized solar cells since its introduction to the field in 1993. However, effective suppression of dye aggregation comes at the cost of reduced dye loading, a lower open-circu ...

WILEY-V C H VERLAG GMBH2020

NTCP deficiency in mice protects against obesity and hepatosteatosis

Kristina Schoonjans

Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na+ taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma. R ...

AMER SOC CLINICAL INVESTIGATION INC2019

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells

Kristina Schoonjans, Alessia Perino

Bile acids and epithelial-derived human beta-defensins (H beta Ds) are known to be important factors in the regulation of colonic mucosal barrier function and inflammation. We hypothesized that bile acids regulate colonic H beta D expression and aimed to t ...

Federation of American Society of Experimental Biology2017

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Acide désoxycholique

Molecular physiology of bile acid signaling in health, disease, and aging

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Biogeography and biochemistry of bile acid 7-dehydroxylation in the mammalian gut

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Bioavailability of steroid hormones sorbed on microplastics for aquatic organisms through biological fluids

First Report of Chenodeoxycholic Acid-Substituted Dyes Improving the Dye Monolayer Quality in Dye-Sensitized Solar Cells

NTCP deficiency in mice protects against obesity and hepatosteatosis

Micellization behavior of bile salt with pluronic (F-127) and synthesis of silver nanoparticles in a mixed system

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells

Graph Chatbot

Chattez avec Graph Search

Biogeography and biochemistry of bile acid 7-dehydroxylation in the mammalian gut

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Molecular physiology of bile acid signaling in health, disease, and aging

Bioavailability of steroid hormones sorbed on microplastics for aquatic organisms through biological fluids

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells

NTCP deficiency in mice protects against obesity and hepatosteatosis

First Report of Chenodeoxycholic Acid-Substituted Dyes Improving the Dye Monolayer Quality in Dye-Sensitized Solar Cells

Micellization behavior of bile salt with pluronic (F-127) and synthesis of silver nanoparticles in a mixed system