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In the developing heart, a subset of endothelial cells (ECs) undergo a process of endothelial to mesenchymal transformation (EMT) that leads to the remodeling of the cardiac cushions and the formation of the cardiac valves. Understanding how microenvironme ...
Genetic defects in autosomal dominant polycystic kidney disease (ADPKD) promote cystic growth of renal tubules, at least in part by stimulating the accumulation of cAMP. How renal cAMP levels are regulated is incompletely understood. We show that cAMP and ...
A uniaxial compressive stress significantly modifies the dielectric and piezoelectric response of Pb(Zr,Ti)O3 (PZT)-based piezoceramics. In soft PZT, the pre-stress decreases both the piezoelectric coefficient and its increment with increasing dynamical st ...
Radiation defects in CdTe and ZnTe are modeled from first principles. The most important intrinsic defects resulting from cation evaporation or displacement are cation vacancies and tellurium anti-sites, electrically active defects characterized by a low f ...
The concept of CO2 storage relies on the long-term sealing properties of both the geological trap and the wells needed to inject and monitor CO2. Well integrity, a classical topic in the oil and gas industry, is thus critical for the performance of any CO2 ...
The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function, vascular structures provide also a critical interface in the balance of tissue homoeostasis and immune func ...
The risk minimization of carbon dioxide (CO2) storage relies to some extent on well integrity assurance. While chemical reactions between the constitutive materials of the wellbore - such as cement - and stored CO 2 do not jeopardize the efficiency of a de ...
We investigate carbon single-atom and pair defects at the SiC/SiO2 interface as candidate defects for the density of defect states in the SiC band gap. In order to accurately describe the electronic defect levels with respect to the SiC band edges, we use ...
Interventional closure of intracardiac wall defects using occluder devices has evolved as a highly attractive treatment option. However, incomplete and delayed healing reactions often result in a major risk of residual defects, thromboembolism, or device f ...
Helium atoms are known to have a significant impact on materials used in fission and fusion reactors. In particular, the presence of helium atoms can change the mechanical properties and degrade the lifetime of reactors. In order to develop the helium-resi ...