Concept

Radiocontrast agent

Publications associées (99)

Novel chelators for MRI applications

In the last two decades, Magnetic Resonance Imaging (MRI) has evolved into one of the most powerful techniques in diagnostic clinical medicine and biomedical research. MRI is primarily used to produce anatomical images, but may also give information on the ...

EPFL2006

Benefiting from the Unique Properties of Lanthanide Ions

The recent upsurge of interest in contrast agents for magnetic resonance imaging, of luminescent chemosensors for medical diagnostic, and lately, for optical imaging of cells has generated an impressive momentum for the coordination and supramolecular chem ...

2006

Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: an 17O and 1H relaxation study of its Gd(III) complex

André Merbach, Lothar Helm, Eva Jakab Toth, Petra Lebduskova

A DTPA-based chelate containing one phosphinate group was conjugated to a generation 5 polyamidoamine (PAMAM) dendrimer via a benzylthiourea linkage. The Gd(III) complex of this novel conjugate has potential as a contrast agent for magnetic resonance imagi ...

2006

17O nuclear quadrupole coupling constants of water bound to a metal ion: A gadolinium(III) case study

Lothar Helm, Oleg Yazyev

Rotational correlation times of metal ion aqua complexes can be detd. from 17O NMR relaxation rates if the quadrupole coupling const. of the bound water oxygen-17 nucleus is known. The rotational correlation time is an important parameter for the efficienc ...

2006

High Relaxivity Confined to a Small Molecular Space: A Metallostar-Based, Potential MRI Contrast Agent

André Merbach, Alain Borel, Eva Jakab Toth, Joao Bruno Livramento Fig.

Good things come in small packages: For its moderate molecular weight, the metallostar complex [Fe{Gd2L(H2O)4}3]4− (see picture; L is a bipyridine–poly(aminocarboxylate) derivative) displays exceptionally high proton relaxivity, which is explained in terms ...

2005

New strategies for highly efficient medical MRI contrast agents

Sabrina Laus

During the last two decades, magnetic resonance imaging (MRI) has evolved into one of the most powerful techniques in medical diagnosis. Among the various medical diagnostic modalities, such as X-ray or ultra-sound imaging, MRI is the technique of choice e ...

EPFL2005

Reactivity of manganese, technetium and rhenium aquacarbonyl-complexes as potential precursors for radiopharmaceuticals

Pascal Grundler

Technetium is an artificial element and its isotope 99mTc is now used for several years as radio-imaging agent. Much research effort is directed towards enhanced targeting of the imaging agents in order to improve accuracy of the diagnosis and reduce the r ...

EPFL2005

Dinuclear gadolinium (III) chelates

Jéröme Costa

In 2003, the Nobel Assembly at the Karolinska Institute has awarded the Nobel Prize in Medicine or Physiology to Paul Lauterbur and Peter Mansfield for their seminal discoveries concerning the development of Magnetic Resonance Imaging (MRI), a non-invasive ...

EPFL2005

Water-Soluble Gadofullerenes: Toward High-Relaxivity, pH-Responsive MRI Contrast Agents

André Merbach, Lothar Helm, Alain Borel, Eva Jakab Toth

The water-soluble endohedral gadofullerene derivatives, Gd@C60(OH)x and Gd@C60[C(COOH)2]10, have been characterized with regard to their MRI contrast agent properties. Water-proton relaxivities have been measured in aqueous solution at variable temperature ...

2005

Synchrotron microangiography with no contrast agent

Giorgio Margaritondo, Amela Groso

Coherent x-rays from synchrotron sources are increasingly used in non-conventional radiological techniques ('phase-contrast' radiology). Our experiments demonstrate that by using white (unmonochromatic) radiation and a time-resolving system, it is possible ...

2004

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