Concept
Méthylation
Publications associées (76)
Anaerobic arsenic methylation as a microbial warfare strategy
Rizlan Bernier-Latmani, Karin Lederballe Meibom, Nicolas Louis Maurice Jacquemin, Hugo Sallet, Jiangtao Qiao
Microbial arsenic methylation is established as a detoxification process under aerobic conditions (converting arsenite to monomethylated arsenate) but proposed to be a microbial warfare strategy under anoxic conditions due to the toxicity of its main produ ...
2023DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
Background Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and development. Early and late pubertal onset are both associated with various diseases developing later in life, and epigenetic c ...
London2023Epigenome-wide DNA methylation in externalizing behaviours: A review and combined analysis
Maria del Carmen Sandi Perez, Mandy Meijer
DNA methylation (DNAm) is one of the most frequently studied epigenetic mechanisms facilitating the interplay of genomic and environmental factors, which can contribute to externalizing behaviours and related psychiatric disorders. Previous epigenome-wide ...
PERGAMON-ELSEVIER SCIENCE LTD2023Nutrient Metabolites Associated With Low D3Cr Muscle Mass, Strength, and Physical Performance in Older Men
Background: The relationship between amino acids, B vitamins, and their metabolites with D3-creatine (D3Cr) dilution muscle mass, a more direct measure of skeletal muscle mass, has not been investigated. We aimed to assess associations of plasma metabolite ...
Cary2023Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years
Jacques Fellay, Christian Axel Wandall Thorball
Background Accelerated epigenetic ageing can occur in untreated HIV infection and is partially reversible with effective antiretroviral therapy (ART). We aimed to make a long-term comparison of epigenetic ageing dynamics in people with HIV during untreated ...
ELSEVIER2023Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells
Beat Fierz, Pablo Rivera Fuentes, Nora Guidotti, Maxime Nicolas Mivelaz, Adam Miklos Eördögh
Chromatin is spatially organized into functional states that are defined by both the presence of specific histone post-translational modifications (PTMs) and a defined set of chromatin-associated “reader” proteins. Different models for the underlying mecha ...
2022Simultaneous Generation of Methyl Esters and CO in Lignin Transformation
Paul Joseph Dyson, Mingyang Liu
Lignin is an abundant renewable carbon source. Due to its complex structure, utilization of lignin is very challenging. Herein, we describe an efficient strategy for the simultaneous utilization of lignin, in which the methoxy groups in lignin react with c ...
WILEY-V C H VERLAG GMBH2022Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish
H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development as it is widely expressed in the eye, peripheral ganglia and branchial arches. Mutations in HMX1 are linked to an ocular defect termed Oculo-auricular syndrome of Schorderet ...
2021High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites
Binding of mammalian transcription factors (TFs) to regulatory regions is hindered by chromatin compaction and DNA methylation of their binding sites. Nevertheless, pioneer transcription factors (PFs), a distinct class of TFs, have the ability to access nu ...
NATURE RESEARCH2021m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner
Andrea Ablasser, Muhammet Fatih Gülen
Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N-6 position of adenines (m6A), a modification that is rare in mammalian host DNA. We show ...
ROYAL SOC2021