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Psychologie du développement

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Comparative Transcriptomics Analyses across Species, Organs, and Developmental Stages Reveal Functionally Constrained lncRNAs

Fabrice Daniel Darbellay, Anamaria Necsulea

The functionality of long noncoding RNAs (lncRNAs) is disputed. In general, lncRNAs are under weak selective pressures, suggesting that the majority of lncRNAs may be nonfunctional. However, although some surveys showed negligible phenotypic effects upon l ...

OXFORD UNIV PRESS2020

How ageing shapes body and space representations: A comparison study between healthy young and older adults

Olaf Blanke, Andrea Serino, Michela Bassolino, Matteo Franza, Giuliana Sorrentino, Charlène Zuber

To efficiently interact with the external world, the brain needs to represent the size of the involved body parts - body representations (BR) - and the space around the body in which the interactions with the environment take place - peripersonal space rep ...

2020

Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS

Maude Schneider, Daniela Maria Zöller, Marie Schaer, Maria Carmela Padula

Disruptions of white matter microstructure have been widely reported in schizophrenia. However, the emergence of these alterations during preclinical stages remains poorly understood. 22q11.2 Deletion Syndrome (22q11.2DS) represents a unique model to study ...

SPRINGERNATURE2020

A community-based transcriptomics classification and nomenclature of neocortical cell types

Parviz Ghaderi, Jean Rossier

To understand the function of cortical circuits, it is necessary to catalog their cellular diversity. Past attempts to do so using anatomical, physiological or molecular features of cortical cells have not resulted in a unified taxonomy of neuronal or glia ...

NATURE PUBLISHING GROUP2020

Gene expression across mammalian organ development

Maria del Carmen Sandi Perez, Ioannis Xenarios

The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early or ...

2019

Topological principles and developmental algorithms might refine diffusion tractography

Jean-Philippe Thiran, Gabriel Girard, Alessandro Daducci, Maxime Descoteaux, Giorgio Innocenti, Tim Bjørn Dyrby

The identification and reconstruction of axonal pathways in the living brain or “ex-vivo” is promising a revolution in connectivity studies bridging the gap from animal to human neuroanatomy with extensions to brain structural–functional correlates. Unfort ...

2019

Regional T-1 mapping of the whole cervical spinal cord using an optimized MP2RAGE sequence

Tobias Kober

While T1 measurements present multiple challenges (robustness, acquisition time), the recently proposed MP2RAGE sequence (magnetization-prepared two rapid acquisition gradient echoes) has opened new perspectives to characterize tissue microstructure change ...

WILEY2019

Social babbling: The emergence of symbolic gestures and words

Aude Billard, Laura Bénédicte Marine Cohen

Language acquisition theories classically distinguish passive language understanding from active language production. However, recent findings show that brain areas such as Broca's region are shared in language understanding and production. Furthermore, th ...

PERGAMON-ELSEVIER SCIENCE LTD2018

Microfluidic high-content phenotypic screening on a Caenorhabditis elegans model

Maria Cristina Letizia

Caenorhabditis elegans is a performant model system for studying human biological processes and diseases and for pre-clinical phenotyping screenings of compounds. Microfluidics has been instrumental in enabling C. elegans-based drug assays, facilitating th ...

EPFL2018

Glycosphingolipid metabolism in cell fate specification

Giovanni D'Angelo, Laura Capolupo, Jaipreet Singh Loomba

Glycosphingolipids (GSLs) are ubiquitous components of eukaryotic plasma membranes that consist of a ceramide backbone linked to a glycan moiety. Both the ceramide and the glycan parts of GSLs display structural variations that result in a remarkable reper ...

2018

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