Concept

Drosophile

Publications associées (137)

Whole-embryo modeling of early segmentation in Drosophila identifies robust and fragile expression domains

Felix Naef, Christian Antonio Pozzorini, Jonathan Bieler

Segmentation of the Drosophila melanogaster embryo results from the dynamic establishment of spatial mRNA and protein patterns. Here, we exploit recent temporal mRNA and protein expression measurements on the full surface of the blastoderm to calibrate a d ...

2011

A novel approach to dielectrophoresis using carbon electrodes

Philippe Renaud, Rodrigo Martinez Duarte

Carbon-electrode dielectrophoresis (carbon-DEP) is demonstrated here as an alternative to more traditional DEP techniques. Carbon-DEP combines advantages of metal-electrode and insulator-based DEP by using low-cost fabrication techniques and low voltages f ...

Wiley-Blackwell2011

Quantitative analysis of gene regulation in Drosophila

Antonina Iagovitina

In this project, characterization of the MAPK signaling cascade was done using the terminal patterning of Drosophila embryo as an experimental system. MAPK acts downstream of the Torso receptor tyrosine kinase (RTK) whose activation is limited to the poles ...

2010

Stabilizing patterning in the Drosophila segment polarity network by selecting models in silico

Felix Naef, Jacques Rougemont, Mirko Bischofberger

The segmentation of Drosophila is a prime model to study spatial patterning during embryogenesis. The spatial expression of segment polarity genes results from a complex network of interacting proteins whose expression products are maintained after success ...

Elsevier2010

Analysis of a specific modular serine protease acting in the Drosophila Toll pathway

Valentin Sottas

In Drosophila, the Toll pathway plays an important role in the immune defense against Gram-positive bacteria and fungi. Molecular determinants coming from those pathogens are directly detected by pattern recognition receptors (PPRs) circulating in the hemo ...

2009

Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation

Bruno Lemaitre, Nichole Broderick

Although Drosophila systemic immunity is extensively studied, little is known about the fly's intestine-specific responses to bacterial infection. Global gene expression analysis of Drosophila intestinal tissue to oral infection with the Gram-negative bact ...

2009

Recognition and response to microbial infection in Drosophila

Bruno Lemaitre, Nichole Broderick

This chapter discusses the mechanisms whereby Drosophila recognize foreign microbes, the signalling systems that regulate adapted responses against them, and the effector mechanisms used to control them. It first focuses on the so-called systemic antimicro ...

Oxford University Press2009

Coupling the cell cycle to development

Pierre Gönczy, Yemima Suryani Budirahardja

The core machinery that drives the eukaryotic cell cycle has been thoroughly investigated over the course of the past three decades. It is only more recently, however, that light has been shed on the mechanisms by which elements of this core machinery are ...

2009

Phase-contrast and fluorescence X-ray imaging of soft and bio matter

Vincent Gajdosik

The high brightness and coherence of X-ray synchrotron sources and steady development in X-ray optics are critical ingredients in novel imaging techniques for a variety of domains. We employed several different approaches and a wide energy spectrum of radi ...

EPFL2009

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

Bruno Lemaitre, Valentin Sottas

The Drosophila Toll receptor does not interact directly with microbial determinants, but is instead activated by a cleaved form of the cytokine-like molecule Spätzle. During the immune response, Spätzle is processed by complex cascades of serine proteases, ...

National Academy of Sciences2009

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