Concept
Denosumab
Publications associées (7)
In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation
Dominique Pioletti, Ulrike Kettenberger
Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...
Wiley-Blackwell2017Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss
Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix deposition and mineralization. Bone homeostasis is altered in chronic inflammation as well as in post-menopausal loss of estrogen, which favors osteoclast activity ...
Public Library of Science2014High hopes for RANKL: will the mouse model live up to its promise?
The steroid hormones, estrogens and progesterone are key drivers of postnatal breast development and are linked to breast carcinogenesis. Experiments in the mouse mammary gland have revealed that they rely on paracrine factors to relegate their signal loca ...
BioMed Central2011Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats
Dominique Pioletti, Randoald Müller, Bastian Peter
Patients with osteoporosis and joint disabilities represent a constant growing and challenging population to be treated in the musculoskeletal clinical field. Especially in the case of total hip arthroplasty, new solutions should be developed to compensate ...
2006Orthopedic implants used as drug delivery systems
Total Hip Replacement (THR) is today a routine procedure executed more than 800'000 times per year worldwide. THR gives generally satisfactory results, although the quality of outcome is inversely proportional to the age of the patient. In parallel, there ...
EPFL2004Can the increase of bone mineral density following bisphosphonates treatments be explained by biomechanical considerations?
Dominique Pioletti, Lalaonirina Rakotomanana Ravelonarivo
OBJECTIVE: We hypothesized that bone mineral density increase following bisphosphonates treatments may be explained by the influence of the drug on the mechanical bone remodeling parameters. BACKGROUND: Patients treated with bisphosphonates continuously in ...
2004