Publications associées à Corneal endothelium

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants

Francesco Stellacci, Evangelia-Nefeli Athanasopoulou

Collagen-rich tissues in the cornea exhibit unique and highly organized extracellular matrix ultrastructures, which contribute to its high load-bearing capacity and light transmittance. Corneal collagen fibrils are controlled during development by small le ...

WILEY-V C H VERLAG GMBH2018

Corneal epithelial stem cells and their niche at a glance

Freddy Radtke, Craig Nowell

The corneal epitheliumacts as a protective barrier on the anterior ocular surface and is essential for maintaining transparency of the cornea and thus visual acuity. During both homeostasis and repair, the corneal epithelium is maintained by self-renewing ...

Company Of Biologists Ltd2017

Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation

Jörg Hülsken, Zuzana Tatárová

Hematopoietic stem cell (HSC) transplantation represents a curative treatment for various hematological disorders. However, delayed reconstitution of innate and adaptive immunity often causes fatal complications. HSC maintenance and lineage differentiation ...

Cell Press2017

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

Freddy Radtke, Matthias Lütolf, Yann Barrandon, Georg Fantner, Sylke Höhnel, Pascal Damian Odermatt, Craig Nowell, Luca Azzolin

Chronic inflammation is associated with a variety of pathological conditions in epithelial tissues, including cancer, metaplasia and aberrant wound healing. In relation to this, a significant body of evidence suggests that aberration of epithelial stem and ...

Nature Publishing Group2016

Mechanical and Functional Study of Cell Physiology at the Nanoscale

Pascal Damian Odermatt

By live-cell imaging of biological samples dynamic cellular processes can be resolved. Fluorescence microscopy (FM) and atomic force microscopy (AFM) are both capable of imaging live cells. By combining these techniques structural as well as functional inf ...

EPFL2016

Enrichment of pathogenic alleles in the brittle cornea gene, ZNF469, in keratoconus

Keratoconus, a common inherited ocular disorder resulting in progressive corneal thinning, is the leading indication for corneal transplantation in the developed world. Genome-wide association studies have identified common SNPs 100 kb upstream of ZNF469 s ...

Oxford University Press2014

Innovative strategy of corneal epithelium regeneration using fabricated soft contact lens containing cavities for stem cells transplantation

Julien Graber

Transplantation of donor cornea is widely performed with a high success rate to treat patients with impaired corneal transparency. However the limited number of donors has led scientists to search for new technologies and treatments, including stem cell th ...

EPFL2014

A New Adjustable Glaucoma Drainage Device

Nikolaos Stergiopoulos, Sylvain Roy, Adan Villamarin, Stéphane Bigler

PURPOSE. This work is focused on the testing of a new experimental noninvasively adjustable glaucoma drainage device (AGDD) that allows for the control of its outflow resistance to modulate intraocular pressure (IOP) in a customized fashion. METHODS. Six A ...

Association for Research in Vision and Ophthalmology2014

A New Noninvasively Adjustable Glaucoma Drainage Device

Adan Villamarin

Glaucoma is an irreversible disease affecting the eye, leading to progressive loss of vision and eventually to total blindness. It is often related to high intraocular pressure (IOP), which results from increased outflow resistance to aqueous humor. The fi ...

EPFL2014

Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway

Yann Barrandon

Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a target of Wnt signaling, is reportedly a marker of intestine, stomach, and hair follicle stem cells in mice. To gain a novel insight into the role of LGR5 in human corneal tissue, we per ...

Wiley-Blackwell2013