Concept

Corneal endothelium

Publications associées (35)

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Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway

Yann Barrandon

Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a target of Wnt signaling, is reportedly a marker of intestine, stomach, and hair follicle stem cells in mice. To gain a novel insight into the role of LGR5 in human corneal tissue, we per ...

Wiley-Blackwell2013

3D simulation of the aqueous flow in the human eye

Nikolaos Stergiopoulos, Sylvain Roy, Adan Villamarin, Philippe Reymond, Orestis Vardoulis, Reda Hasballa

Glaucoma results in an increase in the resistance of the aqueous humor outflow, which in turn leads to an increase of the intraocular pressure (IOP). Several treatments are proposed to reduce and stabilize the IOP that include medications, filtering surger ...

Elsevier Sci Ltd2012

The functional analysis of Lrig1 in the mouse cornea

Andrea Zaffalon

Regenerative medicine aims to recreate functional tissues in vitro for the regeneration of damaged organs and solve the dramatic problem of transplant rejection. Cornea integrity is primordial for our vision. Several therapies to regenerate healthy corneal ...

2011

Sutureless ocular surface reconstruction

Basile Salmon

Corneal diseases account for eight million blind people worldwide, making up to 10% of all causes of blindness. As 80% of the information is collected by our senses, blindness is a very invalidating condition which lowers greatly patients’ quality of life. ...

2010

Essential Role for Pbx1 in Corneal Morphogenesis

PURPOSE. The Pbx TALE (three-amino-acid loop extension) homeodomain proteins interact with class 1 Hox proteins, which are master regulators of cell fate decisions. This study was performed to elucidate the role of the Pbx1 TALE protein in the corneal epit ...

2010

Simulation of the Outflow Pathway in the Human Eye

Nikolaos Stergiopoulos, Sylvain Roy, Philippe Reymond, Andreas Schmocker, Orestis Vardoulis

The eye structure and function highly depend on the stability of the intraocular pressure (IOP). Glaucoma is an ophthalmic disease that can potentially lead to irreversible blindness. Glaucoma results from optic nerve damages due to persistent elevated IOP ...

Springer, 233 Spring Street, New York, Ny 10013, United States2010

Second harmonic generating (SHG) Nanoprobes: A new tool for biomedical imaging

Demetri Psaltis, Ye Pu

Cornea functions as an outermost lens and plays an important role in vision. For cornea diagnosis and treatment, a microscopic imaging system with cellular resolution and high eye safety is strongly desired. Recently, the cell morphology of corneal epithel ...

2009

Modeling the cornea: an architectural approach

Julien Graber

Nowadays the mechanism regulating the corneal epithelium renewal still remains unclear. Until now it was thought to be the fact of stem cells distributed in the limbus, generating TA cells migrating towards the central cornea and responsible for its renewa ...

2009

Proteins interacting with PfEMP1 in P. falciparum infected erythrocyte

Damien Jacot

During infection in humans, P. falciparum invades and refurbishes the red blood cells (RBCs) in order to persist and proliferate. Parasite survival depends on expression of a parasite encoded cytoadherence ligand at the surface of the infected RBC called P ...

2009

Oligopotent stem cells are distributed throughout the mammalian ocular surface

Yann Barrandon, Ariane Rochat, Georges Abou Jaoudé

The integrity of the cornea, the most anterior part of the eye, is indispensable for vision. Forty- five million individuals worldwide are bilaterally blind and another 135 million have severely impaired vision in both eyes because of loss of corneal trans ...

2008