Publications associées à Endothelial dysfunction

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis

Atherosclerosis is a lipid driven chronic inflammatory disease that is characterized by the formation of plaques at predilection sites. These predilection sites (side branches, curved segments, and bifurcations) have often been associated with disturbed sh ...

ELSEVIER SCI LTD2021

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

Johan Auwerx, Norman Lionel Moullan, Lei Chen

Long noncoding RNAs (lncRNAs) are emerging regulators of biological processes in the vessel wall; however, their role in atherosclerosis remains poorly defined. We used RNA sequencing to profile lncRNAs derived specifically from the aortic intima of Ldlr(- ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Role of ERK1/2 activation and nNOS uncoupling on endothelial dysfunction induced by lysophosphatidylcholine

Nikolaos Stergiopoulos, Luciano Dos Santos Aggum Capettini

Background and aims: Lysophosphatidylcholine (LPC) - a main component of oxidized LDL -is involved in endothelial dysfunction that precedes atherosclerosis, with an increased superoxide anions and a reduced NO production via endothelial NO synthase (eNOS) ...

Elsevier2017

Perivascular Macrophages Limit Permeability

Michele De Palma, Melody Swartz, Mario Leonardo Squadrito, Witold Waldemar Kilarski, Esra Güç

Objective-Perivascular cells, including pericytes, macrophages, smooth muscle cells, and other specialized cell types, like podocytes, participate in various aspects of vascular function. However, aside from the well-established roles of smooth muscle cell ...

American Heart Association2016

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

Freddy Radtke, Christian Weber

A population of monocytes, known as Ly6C(lo) monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion s ...

Nature Publishing Group2016

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Younouss Faye

IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...

Wiley-Blackwell2015

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

Johan Auwerx, Jiujiu Yu

We report the engineering and characterization of paraoxonase-3 knockout mice (Pon3KO). The mice were generally healthy but exhibited quantitative alterations in bile acid metabolism and a 37% increased body weight compared to the wild-type mice on a high ...

Federation of American Society of Experimental Biology2015

An Oral Formulation of Angiotensin-(1-7) Reverses Corpus Cavernosum Damages Induced by Hypercholesterolemia

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Danielle Gomes Passos Silva

Introduction The renin angiotensin system plays a crucial role in erectile function. It has been shown that elevated angiotensin-II levels contribute to the development of erectile dysfunction (ED). Oppositely, angiotensin-(1-7) (Ang-[1-7]) mediates penile ...

Wiley-Blackwell2013

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Endothelial dysfunction

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

Role of ERK1/2 activation and nNOS uncoupling on endothelial dysfunction induced by lysophosphatidylcholine

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

Perivascular Macrophages Limit Permeability

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

Insights into the antiatherogenic molecular mechanisms of andrographolide against Porphyromonas gingivalis-induced atherosclerosis in rabbits

An Oral Formulation of Angiotensin-(1-7) Reverses Corpus Cavernosum Damages Induced by Hypercholesterolemia

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Chattez avec Graph Search

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

Insights into the antiatherogenic molecular mechanisms of andrographolide against Porphyromonas gingivalis-induced atherosclerosis in rabbits

Role of ERK1/2 activation and nNOS uncoupling on endothelial dysfunction induced by lysophosphatidylcholine

Perivascular Macrophages Limit Permeability

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury

An Oral Formulation of Angiotensin-(1-7) Reverses Corpus Cavernosum Damages Induced by Hypercholesterolemia