Concept
Anxiété
Publications associées (79)
Medium chain triglyceride diet reduces anxiety-like behaviors and enhances social competitiveness in rats
Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Fiona Hollis
Medium-chain triglycerides (MCT) are emerging as unique dietary supplements that are potentially relevant for the amelioration of brain dysfunctions. MCT are converted into ketones and free medium chain fatty acids that, in the brain, are highly effective ...
2018Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors
Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Jocelin Grosse, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Fiona Hollis, Michael van der Kooij, Ioannis Zalachoras, Laura Lozano Montes, Sonia Abad Florensa
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...
Nature Publishing Group2018Alterations in brain microstructure in rats that develop abnormal aggression following peripubertal stress
Maria del Carmen Sandi Perez, Sophie Elizabeth Walker
Exposure to early adversity is implicated in the development of aggressive behaviour later in life in some but not all individuals. The reasons for the variability in response to such experiences are not clear but may relate to pre‐existing individual diff ...
2018GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats
Maria del Carmen Sandi Perez, Michael van der Kooij, Ioannis Zalachoras
Social dominance can be attained through social competitions. Recent work in both humans and rodents has identified trait anxiety as a crucial predictor of social competitiveness. In addition, the anxiolytic GABAA positive modulator, diazepam, injected eit ...
2018In vivo neurochemistry of the ventral striatum and social competition in Homo sapiens
Ventral striatal function and trait anxiety have been shown to influence reward-seeking behaviour and social competition in humans. Moreover, social status perceptions have been shown to modulate ventral striatal function. The neurochemical underpinnings o ...
EPFL2017Constitutive differences in habituation of the glucocorticoid response to stress are related to variation in aggression and anxiety-related behaviors
Maria del Carmen Sandi Perez, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Sophie Elizabeth Walker
Glucocorticoids coordinate responses that enable an individual to cope with stressful challenges and, additionally, mediate adaptation following cessation of a stressor. There are important individual differences in the magnitude of glucocorticoid responsi ...
2017A preclinical model for identifying rats at risk of alcohol use disorder
Pierre Magistretti, Benjamin Boutrel
Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains o ...
Springer Nature2017In the pursuit of the fear engram: identification of neuronal circuits underlying the treatment of anxiety disorder
Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf
Fear and other anxiety disorders are extraordinarily robust and difficult to treat. Among the most effective treatments for anxiety disorders are exposure-based therapies, during which a patient is repeatedly confronted with the originally fear-eliciting s ...
EPFL2017Not all anxious individuals get lost: trait anxiety and mental rotation ability interact to explain performance in map-based route learning in men
Maria del Carmen Sandi Perez, John Christian Thoresen, Rebecca Francelet
Navigation through an environment is a fundamental human activity. Although group differences in navigational ability are documented (e.g., gender), little is known about traits that predict these abilities. Apart from a well-established link between menta ...
2016