Concept
Lipoprotéine
Publications associées (32)
NTCP deficiency in mice protects against obesity and hepatosteatosis
Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na+ taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma. R ...
AMER SOC CLINICAL INVESTIGATION INC2019Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism
Patrick Descombes, Sylviane Métairon, Jörg Hager, Hélène Ruffieux, Nele Gheldof
Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains ...
Springer2019Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates
Kei Sakamoto, Maria Deak, Caterina Collodet, Susanne Seitz
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting as a sensor of energy and nutrient status. As such, AMPK is considered a promising drug target for treatment of medical conditions particularly associated with me ...
ELSEVIER SCIENCE INC2019