Publications associées à Polyclonal B cell response

The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions

LRH-1 (liver receptor homolog-1/NR5a2) is an orphan nuclear receptor, which regulates glucose and lipid metabolism, as well as intestinal inflammation via the transcriptional control of intestinal glucocorticoid synthesis. Predominantly expressed in epithe ...

American Association for the Advancement of Science (AAAS)2019

Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness

Bruno Lemaitre, Mark Austin Hanson

There is a developing interest in how immune genes may function in other physiological roles, and how traditionally non-immune peptides may, in fact, be active in immune contexts. In the absence of infection, the induction of the immune response is costly, ...

FRONTIERS MEDIA SA2019

IL-4R alpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells

Nicola Harris, Lalit Kumar Dubey

Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5(+) dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of ...

CELL PRESS2019

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Nicola Harris, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery

Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...

WILEY2019

Nucleic acids presenting polymer nanomaterials as vaccine adjuvants

Maartje Martina Cornelia Bastings, Kaltrina Paloja, Alice Comberlato

Most vaccines developed today include only the antigens that best stimulate the immune system rather than the entire virus or microbe, which makes vaccine production and use safer and easier, though they lack potency to induce acceptable immunity and long- ...

ROYAL SOC CHEMISTRY2019

Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes

Xavier Fredy René Quaglia-Thermes, Giacomo Olimpio Diaceri, Jeffrey Alan Hubbell, Sachiko Hirosue, David Scott Wilson, Martina Damo, Michal Mateusz Raczy

Homeostatic antigen presentation by hepatic antigen-presenting cells, which results in tolerogenic T-cell education, could be exploited to induce antigen-specific immunological tolerance. Here we show that antigens modified with polymeric forms of either N ...

2019

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress

John McKinney, Neeraj Dhar, Giulia Manina, Lalit Kumar Singh

Clonal microbial populations are inherently heterogeneous, and this diversification is often considered as an adaptation strategy. In clinical infections, phenotypic diversity is found to be associated with drug tolerance, which in turn could evolve into g ...

2019

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

Henning Paul-Julius Stahlberg

High specificity accompanied with the ability to recruit immune cells has made recombinant therapeutic antibodies an integral part of drug development. Here we present a generic approach to generate two novel IgG-derived antibody formats that are based on ...

Informa UK Limited2019

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Polyclonal B cell response

The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions

Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness

The role of mechanical hysteresis source in mechanical and mechanobiological performances of load-bearing biomaterials

Expanding beyond the natural protein repertoire to engineer targeted vaccines and diagnostics

IL-4R alpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Nucleic acids presenting polymer nanomaterials as vaccine adjuvants

Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

Graph Chatbot

Chattez avec Graph Search

IL-4R alpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells

The role of mechanical hysteresis source in mechanical and mechanobiological performances of load-bearing biomaterials

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions

Expanding beyond the natural protein repertoire to engineer targeted vaccines and diagnostics

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness

Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes

Nucleic acids presenting polymer nanomaterials as vaccine adjuvants

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress