Concept

Modified-release dosage

Publications associées (101)

Microfluidics: A Tool to Control the Size and Composition of Particles

Particles and capsules are used as containers for active ingredients to delay their degradation and control the location and kinetics of their release. Key to a successful application of these containers is a good control over their size, composition, and ...

Swiss Chemical Soc2017

Swimming with a cage: low-Reynolds-number locomotion inside a droplet

François Gallaire, Lailai Zhu

Inspired by recent experiments using synthetic microswimmers to manipulate droplets, we investigate the low-Reynolds-number locomotion of a model swimmer (a spherical squirmer) encapsulated inside a droplet of a comparable size in another viscous fluid. Me ...

Royal Society of Chemistry2017

High-fidelity numerical analysis of experimental tests on concrete specimens via mixed strain-displacement FE

Lorenzo Benedetti

The experimental characterization of brittle and quasi brittle materials such as concrete is a complex and challenging topic. In this framework, numerical analysis can represent a powerful tool to study and validate the possible tests outcome and identify ...

2017

An isogeometric method for linear nearly-incompressible elasticity with local stress projection

Annalisa Buffa, Pablo Antolin Sanchez

In this paper, we propose an isogeometric method for solving the linear nearly-incompressible elasticity problem. The method is similar to the (B) over bar formulation where the volumetric strain is projected on a lower degree spline space in order to prev ...

Elsevier Science Sa2017

Micro- and nanoscale hierarchical structure of core-shell protein microgels

Giovanni Dietler, Francesco Simone Ruggeri, Raffaele Mezzenga

Protein nanofibrils were first discovered in the context of misfolding and neurodegenerative diseases but have recently been found in naturally occurring functional materials including algal adhesives, bacterial coatings, and even mammalian melanosomes. Th ...

Royal Soc Chemistry2016

Cl-35 dynamic nuclear polarization solid-state NMR of active pharmaceutical ingredients

David Lyndon Emsley, Aaron James Rossini

In this work, we show how to obtain efficient dynamic nuclear polarization (DNP) enhanced Cl-35 solid-state NMR (SSNMR) spectra at 9.4 T and demonstrate how they can be used to characterize the molecular-level structure of hydrochloride salts of active pha ...

Royal Society of Chemistry2016

High-fidelity prediction of crack formation in 2D and 3D pullout tests

Lorenzo Benedetti

This paper presents the 2D and 3D numerical analysis of pullout tests on steel anchorages in concrete blocks using standard and mixed finite elements. A novel (stabilized) mixed formulation in the variables of total strain ε and displacements u is introduc ...

Elsevier2016

Kinetics of Ultrasonic Drug Delivery from Targeted Micelles

Jeffrey Alan Hubbell

To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This paper compares the percent drug relea ...

Amer Scientific Publishers2015

Label-Free Detection of Tobramycin in Serum by Transmission-Localized Surface Plasmon Resonance

Carlotta Guiducci, Thierry Buclin, Anna Ferretti, Giulia Cappi, Fabio Mario Spiga, Laurent Décosterd, Michael Beyeler

In order to improve the efficacy and safety of treatments, drug dosage needs to be adjusted to the actual needs of each patient in a truly personalized medicine approach. Key for widespread dosage adjustment is the availability of point-of-care devices abl ...

Amer Chemical Soc2015

A solid-state NMR method to determine domain sizes in multi-component polymer formulations

David Lyndon Emsley, Judith Schlagnitweit

Polymer domain sizes are related to many of the physical properties of polymers. Here we present a solid-state NMR experiment that is capable of measuring domain sizes in multi-component mixtures. The method combines selective excitation of carbon magnetiz ...

Academic Press Inc Elsevier Science2015

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