Concept

Défériprone

Publications associées (4)

Conditional Deletion of Ferritin H in Mice Reduces B and T Lymphocyte Populations

The immune system and iron availability are intimately linked as appropriate iron supply is needed for cell proliferation, while excess iron, as observed in hemochromatosis, may reduce subsets of lymphocytes. We have tested the effects of a ferritin H gene ...

Public Library of Science2014

To live and let die in The Big Blue

Karl Gademann

Harmful algal blooms in both freshwater and marine environments pose significant challenges for humans, livestock and aquatic food webs. Over the last 50 years, several authors proposed that small mol. iron chelators (siderophores) could be responsible for ...

American Chemical Society2008

In vivo and in vitro modulation of the mRNA-binding activity of iron-regulatory factor. Tissue distribution and effects of cell proliferation, iron levels and redox state

Lukas Kühn

The mRNA-binding protein, iron-regulatory factor (IRF) has a central role in iron metabolism. It coordinately increases transferrin-receptor mRNA stability and inhibits translation of ferritin and erythroid delta-aminolevulinate synthase mRNA by binding to ...

1992

Noncoding 3' sequences of the transferrin receptor gene are required for mRNA regulation by iron

Lukas Kühn

The cell-surface receptor for transferrin mediates cellular uptake of iron from serum. Transferrin receptor protein and mRNA levels are increased in cells treated with iron chelating agents, and are decreased by treatment with iron salts or hemin. Here we ...

1987

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