Concept
Radeau lipidique
Publications associées (359)
Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis
Mitochondrial diseases are rare and severe conditions with debilitating symptoms. Biochemical defects in mitochondria however are common. The difference between these two frequencies is suspected to lie in the capability of the cells to adapt to the homeos ...
EPFL2022Solution nuclear magnetic resonance spectroscopy of bacterial outer membrane proteins in natively excreted vesicles using engineered Escherichia coli
Gaining structural information on membrane proteins in their native lipid environment is a long-standing challenge in molecular biology. Instead, it is common to employ membrane mimetics, which has been shown to affect protein structure, dynamics, and func ...
WILEY2022Raman microspectroscopy reveals unsaturation heterogeneity at the lipid droplet level and validates an in vitro model of bone marrow adipocyte subtypes
Olaia Maria Naveiras Torres-Quiroga, Charles Christopher Bataclan, Vasco Ledebur de Antas de Campos, Josefine Catharina Pedersen Tratwal, Daniel Naveed Tavakol
Bone marrow adipocytes (BMAds) constitute the most abundant stromal component of adult human bone marrow. Two subtypes of BMAds have been described, the more labile regulated adipocytes (rBMAds) and the more stable constitutive adipocytes (cBMAds), which d ...
FRONTIERS MEDIA SA2022Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia
Johan Auwerx, Davide D'Amico, Qi Wang, Sébastien Robert Victor Herzig, Maroun Bou Sleiman, Martin Rainer Wohlwend, Peiling Luan, Pirkka-Pekka Untamo Laurila, Barbara Moreira Crisol
Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...
SPRINGERNATURE2022Selective integrin targeting with DNA-based nanomaterials
Targeting cells specific to type and state remains a challenge in developing effective therapies, sensitive diagnostics, also robust and versatile tissue engineering. A promising strategy is to focuses on improving the inherent selectivity of the targeting ...
EPFL2022Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets
Jonathan Paz Montoya, Howard Riezman
Recent evidence suggests that circadian clocks ensure temporal orchestration of lipid homeostasis and play a role in pathophysiology of metabolic diseases in humans, including type 2 diabetes (T2D). Nevertheless, circadian regulation of lipid metabolism in ...
PUBLIC LIBRARY SCIENCE2022Regulation of Src tumor activity by its N-terminal intrinsically disordered region
Romain Hamelin, Florence Armand
The membrane-anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conform ...
SPRINGERNATURE2022Post-translational regulation of neuronal differentiation
Glycosphingolipids (GSLs) are amphipathic lipid moieties that make up only 3% of the total lipid content of the cell and are almost exclusively expressed at the Plasma Membrane(PM). They are key drivers of signalling hotspots known as âlipid-raftsâ as ...
EPFL2021S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel a ...
eLIFE SCIENCES PUBL LTD2021Influence of Detergent and Lipid Composition on Reconstituted Membrane Proteins for Structural Studies
Membrane proteins are frequently reconstituted in different detergents as a prerequisite to create a phospholipid environment reminiscent of their native environment. Different detergent characteristics such as their chain length and bond types could affec ...
AMER CHEMICAL SOC2021