Publications associées à Transthyrétine

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Johan Auwerx, Mario Romani, Tanes Imamura de Lima, Hao Li, Vincenzo Sorrentino, Hongbo Zhang

Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging and diseases. Moreover, we show accumulation of amyloid-like d ...

2021

Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity

Bruno Emanuel Ferreira De Sousa Correia

One of the molecular hallmarks of amyloidoses is ordered protein aggregation involving the initial formation of soluble protein oligomers that eventually grow into insoluble fibrils. The identification and characterization of molecular species critical fo ...

2020

Effects of sedimentation, microgravity, hydrodynamic mixing and air-water interface on alpha-synuclein amyloid formation

Giovanni Dietler, Giovanni Longo, Francesco Simone Ruggeri, Jiangtao Zhou

The formation of amyloid fibrils is a characterizing feature of a range of protein misfolding diseases, including Parkinson's disease. The propensity of native proteins to form such amyloid fibril, both in vitro and in vivo, is highly sensitive to the surr ...

ROYAL SOC CHEMISTRY2020

Membrane–Protein–Hydration Interaction of α-Synuclein with Anionic Vesicles Probed via Angle-Resolved Second-Harmonic Scattering

Sylvie Roke, Jan Dedic, Halil Ibrahim Okur

Amyloid formation of the protein α-synuclein promotes neurodegeneration in Parkinson's disease. The normal function of α-synuclein includes synaptic vesicle transport and fusion, and the protein binds strongly to negatively charged vesicles in vitro. Here, ...

2019

Initial Steps of Amyloidogenic Peptide Assembly Revealed by Cold-Ion Spectroscopy

Vladimir Kopysov, Natalia Nagornova

The early stages of fibril formation are difficult to capture in solution. We use cold-ion spectroscopy to examine an 11-residue peptide derived from the protein transthyretin and clusters of this fibre-forming peptide containing up to five units in the ga ...

Wiley-Blackwell2018

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Johan Auwerx, Davide D'Amico, Adrian Schmid, Norman Lionel Moullan, Vincenzo Sorrentino, Hongbo Zhang, Francesca Potenza, Solene Rietsch

Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provid ...

Nature Publishing Group2017

Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection

Giovanni Dietler, Hilal Lashuel, Sandor Kasas, Anne-Laure Mahul Mellier, Giovanni Longo, Francesco Simone Ruggeri

Cells are extremely complex systems able to modify actively their metabolism and behaviour in response to environmental conditions and stimuli, such as pathogenic agents or drugs. The comprehension of these responses is central to understand the molecular ...

Springer Nature2017

Formation of Large Hypericin Aggregates in Giant Unilamellar Vesicles-Experiments and Modeling

Jaroslava Joniová, Veronika Huntosova

The incorporation of hypericin (Hyp) from aqueous solutions into giant unilamellar vesicle (GUV) membranes has been studied experimentally and by means of kinetic Monte Carlo modeling. The time evolution of Hyp fluorescence originating from Hyp monomers di ...

Cell Press2017

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Transthyrétine

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity

Effects of sedimentation, microgravity, hydrodynamic mixing and air-water interface on alpha-synuclein amyloid formation

Nanoscale Characterization of Amyloid Fibrils and Biomacromolecules by Atomic Force Microscopy Approaches

Membrane–Protein–Hydration Interaction of α-Synuclein with Anionic Vesicles Probed via Angle-Resolved Second-Harmonic Scattering

Initial Steps of Amyloidogenic Peptide Assembly Revealed by Cold-Ion Spectroscopy

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection

Formation of Large Hypericin Aggregates in Giant Unilamellar Vesicles-Experiments and Modeling

Graph Chatbot

Chattez avec Graph Search

Membrane–Protein–Hydration Interaction of α-Synuclein with Anionic Vesicles Probed via Angle-Resolved Second-Harmonic Scattering

Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Effects of sedimentation, microgravity, hydrodynamic mixing and air-water interface on alpha-synuclein amyloid formation

Oligomerization Profile of Human Transthyretin Variants with Distinct Amyloidogenicity

Nanoscale Characterization of Amyloid Fibrils and Biomacromolecules by Atomic Force Microscopy Approaches

Initial Steps of Amyloidogenic Peptide Assembly Revealed by Cold-Ion Spectroscopy

Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection

Formation of Large Hypericin Aggregates in Giant Unilamellar Vesicles-Experiments and Modeling

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity