Concept

Cytochrome c oxydase

Publications associées (58)

Sensing the dynamics of oxidative stress using enhanced absorption in protein-loaded random media

Olivier Martin, Christian Santschi, Guillaume Suarez

Reactive oxygen species play a key role in cell signalling and oxidative stress mechanisms, therefore, sensing their production by living organisms is of fundamental interest. Here we describe a novel biosensing method for extracellular detection of endoge ...

Nature Publishing Group2013

Mitochondrial ribosomal proteins as aging regulators

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including ...

2013

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

Johan Auwerx, Richardus Houtkooper, Ivan Stamenkovic, Michalina Janiszewska

Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. ...

Cold Spring Harbor Lab Press, Publications Dept2012

Self-Assembled Molecular Rafts at Liquid|Liquid Interfaces for Four-Electron Oxygen Reduction

Hubert Girault, Jiri Vanicek, Astrid Johana Olaya Avendano, Pierre-François Marie Brevet, Tomas Zimmermann

The self-assembly of the oppositely charged watersoluble porphyrins, cobalt tetramethylpyridinium porphyrin (CoTMPyP4+) and cobalt tetrasulphonatophenyl porphyrin (CoTPPS4−), at the interface with an organic solvent to form molecular “rafts”, provides an e ...

2012

The response of Desulfotomaculum reducens MI-1 to U(VI) exposure: a transcriptomic study

Rizlan Bernier-Latmani, Elena Cristina Dalla Vecchia

Desulfotomaculum reducens is the first Gram-positive sulfate- and metal-reducing bacterium for which the transcriptomic response to uranium exposure has been evaluated. The genes upregulated during fermentative growth in the presence of U(VI) as compared t ...

Taylor & Francis2011

Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(II) compounds with sulfur and phosphorus donors

Angela Casini

Twelve Pt(II) complexes with cis-PtP2S2 pharmacophores (where P-2 refers to two monodentate or one bidentate phosphane ligand and S-2 is a dithiolato ligand) were prepared, characterized and evaluated as potential antiproliferative agents. The various comp ...

2011

Four-electron oxygen reduction by Tetrathiafulvalene

Hubert Girault, Astrid Johana Olaya Avendano, Péter Kalman Péchy, Jérôme Florian Gonthier, Peiyu Ge

The four-electron reduction of oxygen by tetrathiafulvalene (TTF) in acidified 1,2-dichloroethane and at the acidified water/1,2-dichloroethane interface has been observed. Spectroscopy and ion transfer voltammetry results suggest that the reaction proceed ...

2011

Multiplexing pH and Temperature in a Molecular Biosensor

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Michele Daniel Torre, Daniela De Venuto

Robust and reliable measurements in electrochemical biosensing of molecules are crucial for personalized medicine. Electrochemical sensors based on cytochrome P450 can detect the large majority of drugs commonly used in pharmacological treatments. The same ...

2010

SIRT1 mRNA Expression May Be Associated with Energy Expenditure and Insulin Sensitivity

Johan Auwerx, Hiroyasu Yamamoto

Objective - Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin sensitive tissues is associat ...

2010

The enigmatic role of tafazzin in cardiolipin metabolism

Richardus Houtkooper

The mitochondrial phospholipid cardiolipin plays an important role in cellular metabolism as exemplified by its involvement in mitochondrial energy production and apoptosis. Following its biosynthesis, cardiolipin is actively remodeled to achieve its final ...

2009

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