Publications associées à Phylogenetic comparative methods

From trees to barcodes and back again II: Combinatorial and probabilistic aspects of a topological inverse problem

Kathryn Hess Bellwald, Lida Kanari, Adélie Eliane Garin

In this paper we consider two aspects of the inverse problem of how to construct merge trees realizing a given barcode. Much of our investigation exploits a recently discovered connection between the symmetric group and barcodes in general position, based ...

2024

Impact of phylogeny on structural contact inference from protein sequence data

Anne-Florence Raphaëlle Bitbol, Nicola Dietler, Umberto Lupo

Local and global inference methods have been developed to infer structural contacts from multiple sequence alignments of homologous proteins. They rely on correlations in amino acid usage at contacting sites. Because homologous proteins share a common ance ...

ROYAL SOC2023

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Didier Trono, Laurence Gouzi Abrami, Evaristo Jose Planet Letschert, Julien Léonard Duc, Laia Simo Riudalbas, Sandra Eloise Kjeldsen, Alexandre Coudray, Sagane Dind

The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, upon characterizing cancer-specific transposable element-driven transpochimeric gene transcripts (TcGTs) produced by this tumor in the SYSCOL cohort, we ...

2022

Extracting phylogenetic dimensions of coevolution reveals hidden functional signals

Anne-Florence Raphaëlle Bitbol

Despite the structural and functional information contained in the statistical coupling between pairs of residues in a protein, coevolution associated with function is often obscured by artifactual signals such as genetic drift, which shapes a protein's ph ...

NATURE PORTFOLIO2022

The microbiome of cryospheric ecosystems

Tom Ian Battin, Hannes Markus Peter, Susheel Bhanu Busi, Grégoire Marie Octave Edouard Michoud, Leïla Ezzat, Massimo Bourquin, Tyler Joe Kohler, Stylianos Fodelianakis

The cryosphere includes those parts of Earth where water or soil is frozen, such as snow, ice, glaciers and permafrost soils. Here, the authors present a global inventory of cryospheric microbial communities and their genetic repertoires. The melting of th ...

NATURE PORTFOLIO2022

Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load

Jacques Fellay, Luca Ferretti

Set-point viral load (SPVL), a common measure of human immunodeficiency virus (HIV)-1 virulence, is partially determined by viral genotype. Epidemiological evidence suggests that this viral property has been under stabilising selection, with a typical opti ...

OXFORD UNIV PRESS2022

Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

Bart Deplancke, Bastien Mangeat, Vincent Roland Julien Gardeux, Julie Marie Russeil, Jörn Pezoldt, Elisa Cora, Daniel Alpern

Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden. Despite its close phylogenetic relationship to SARS-CoV, SARS-CoV-2 exhibits increased human-to- ...

PUBLIC LIBRARY SCIENCE2021

MPGM: Scalable and Accurate Multiple Network Alignment

Matthias Grossglauser, Ehsan Kazemi

Protein-protein interaction (PPI) network alignment is a canonical operation to transfer biological knowledge among species. The alignment of PPI-networks has many applications, such as the prediction of protein function, detection of conserved network mot ...

IEEE COMPUTER SOC2020

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Phylogenetic comparative methods

From trees to barcodes and back again II: Combinatorial and probabilistic aspects of a topological inverse problem

The microbial genomics of glacier-fed streams: adaptations to an extreme ecosystem

Towards a metabolic theory of catchments: scaling of water and carbon fluxes with size

Impact of phylogeny on structural contact inference from protein sequence data

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Extracting phylogenetic dimensions of coevolution reveals hidden functional signals

The microbiome of cryospheric ecosystems

Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load

Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

MPGM: Scalable and Accurate Multiple Network Alignment

Graph Chatbot

Chattez avec Graph Search

The microbial genomics of glacier-fed streams: adaptations to an extreme ecosystem

Towards a metabolic theory of catchments: scaling of water and carbon fluxes with size

Extracting phylogenetic dimensions of coevolution reveals hidden functional signals

Impact of phylogeny on structural contact inference from protein sequence data

From trees to barcodes and back again II: Combinatorial and probabilistic aspects of a topological inverse problem

MPGM: Scalable and Accurate Multiple Network Alignment

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

The microbiome of cryospheric ecosystems

Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load

Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium