Concept
Carbidopa
Publications associées (8)
A Multiscale, Systems-Level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching Under Normal, Parkinsonian, and Levodopa Medication Conditions
Vignayanandam Ravindernath Muddapu
In order to understand the link between substantia nigra pars compacta (SNc) cell loss and Parkinson's disease (PD) symptoms, we developed a multiscale computational model that can replicate the symptoms at the behavioural level by incorporating the key ce ...
FRONTIERS MEDIA SA2022Towards elucidating the structural and cellular determinants of a-synuclein seeding and toxicity
Although it has been nearly two and half decades since the discovery of alpha-synuclein (aSyn) as the major component of Lewy bodies (LBs), our understanding of the involvement of different aSyn species, their seeding, spreading and toxicity in Parkinson's ...
EPFL2022Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism
Grégoire Courtine, Eduardo Martin Moraud, Tomislav Milekovic, Shiqi Sun
Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...
2018The anti-Parkinsonian drug selegiline delays the nucleation phase of α-synuclein aggregation leading to the formation of nontoxic species
Hilal Lashuel, Saviana Di Giovanni
Parkinson's disease (PD) is a movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of intraneuronal inclusions called Lewy bodies, which are composed mainly of α-synuclein (α-syn). Selegiline (Sel) i ...
2010Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons
Short-hairpin RNA (shRNA)-mediated gene knockdown is a powerful tool for targeted gene silencing and an emerging novel therapeutic strategy. Recent publications, however, reported unexpected toxicity after utilizing viral-mediated shRNA knockdown in vivo. ...
2009Dopaminergic effects on encoding of a motor memory in chronic stroke
The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability ...
2005In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
The glial cell line-derived neurotrophic factor (GDNF)-family of neurotrophic factors consisted until recently of three members, GDNF, neurturin, and persephin. We describe here the cloning of a new GDNF-family member, neublastin (NBN), identical to artemi ...
2000Dopaminergic supersensitivity induced by denervation and chronic receptor blockade is additive
A persistent, severe reduction of synaptic transmission has been shown to enhance the responsiveness of postsynaptic tissue to the deficient neurotransmitter—a phenomenon called postjunctional supersensitivity. Regardless of whether supersensitivity is ind ...
1982