Concept
Cyclin-dependent kinase 6
Publications associées (48)
Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs
Daniel Constam, Benjamin Marcel Daniel Rothé, Céline Gagnieux, Simon Fortier, Céline Emmanuelle Schmuziger
The growing number of diseases linked to aberrant phase transitioning of ribonucleoproteins highlights the need to uncover how the interplay between multivalent protein and RNA interactions is regulated. Cytoplasmic granules of the RNA binding protein Bica ...
CELL PRESS2023Genomic studies indicate a novel combination therapy for follicular lymphoma COMMENT
Follicular lymphoma (FL) is an incurable form of B-cell lymphoma. Genomic alterations that inactivate RB signaling are surprisingly common in indolent FL. We show that FLs that are positive for phosphorylated RB respond to dual CDK4/BCL2 inhibition. Our re ...
TAYLOR & FRANCIS INC2021CDK4 Phosphorylates AMPK alpha 2 to Inhibit Its Activity and Repress Fatty Acid Oxidation
Anita Nasrallah, Caterina Collodet, Judit Castillo Armengol
The roles of CDK4 in the cell cycle have been extensively studied, but less is known about the mechanisms underlying the metabolic regulation by CDK4. Here, we report that CDK4 promotes anaerobic glycolysis and represses fatty acid oxidation in mouse embry ...
Cell Press2017