Concept

Système endomembranaire

Publications associées (247)

Kinetic modeling of the yeast sphingolipid metabolism identifies prevalent mutant strains through integration of lipidomic data profiles

Vassily Hatzimanikatis, Paolo Angelino, Howard Riezman, Georgios Savoglidis

Sphingolipids are abundant components of eukaryotic cells. Their localization in the plasma membrane allows for the cell to carry out multiple important functions for its viability. One of the most important roles of the sphingolipids is their ability to f ...

2012

Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo

Bernard Schneider, Ying Liu, Philippe Guillaume Coune

Accumulation of misfolded alpha-synuclein (alpha S) is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other alpha-synucleinopathies. However, how alpha S causes neurodegeneration is unresolved. Because cellular accumulation of ...

Society for Neuroscience2012

Topology of evolving pore networks

Emmanuel Gallucci, Marco Stampanoni

Morphological and topological quantification of complex pore networks is of great relevance for environmental engineering, earth science and industry. Recent developments of 3D imaging techniques such as X-ray microtomography or X-ray microscopy provide an ...

Edp Sciences S A2012

ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER

Maurizio Molinari, Riccardo Bernasconi

The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins in eukaryotic cells. Unsuccessful folding attempts are eventually interrupted and most folding-defective polypeptides are dislocated across the ER membrane and deg ...

2011

Theoretical treatment and numerical simulation of potentiometric and amperometric enzyme electrodes and of enzyme reactors. Part 2: Time-dependent concentration profiles, fluxes, and responses

Nico de Rooij, Peter Van der Wal

The time-dependent behavior of sensor systems based on enzyme membranes is treated theoretically. The comparative treatment covers traditional potentiometric and amperometric enzyme electrodes as well as enzyme reactors. Theoretical solutions are derived b ...

2011

Unconventional Use of LC3 by Coronaviruses through the Alleged Subversion of the ERAD Tuning Pathway

Maurizio Molinari

Pathogens of bacterial and viral origin hijack pathways operating in eukaryotic cells in many ways in order to gain access into the host, to establish themselves and to eventually produce their progeny. The detailed molecular characterization of the subver ...

2011

Alpha-Synuclein Effects at the ER-to-Golgi Level and Potential Biomarkers in Rat Models of the Early Phase of Parkinson's Disease

Philippe Guillaume Coune

While Parkinson's disease has been described nearly 200 years ago, the mechanisms leading to the degeneration of selectively vulnerable populations of neurons, such as dopaminergic neurons in the substantia nigra, remain mostly unknown. Our poor understand ...

EPFL2011

Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions

Li Tang, Amaresh Mishra

Cell-penetrating peptides (CPPs), such as the HIV TAT peptide, are able to translocate across cellular membranes efficiently. A number of mechanisms, from direct entry to various endocytotic mechanisms (both receptor independent and receptor dependent), ha ...

2011

Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun, Philippe Guillaume Coune

Although the overabundance of human alpha-synuclein in nigral dopaminergic neurons is considered to play a pathogenic role in Parkinson's disease (PD), it remains unclear how alpha-synuclein leads to neuronal degeneration and motor symptoms. Here, we explo ...

Ios Press2011

Optomechanical Coupling in a Two-Dimensional Photonic Crystal Defect Cavity

Tobias Kippenberg, Emanuel Gavartin

Periodically structured materials can sustain both optical and mechanical modes. Here we investigate and observe experimentally the optomechanical properties of a conventional two-dimensional suspended photonic crystal defect cavity with a mode volume of s ...

2011

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