Publications de Manuel Bauer | EPFL Graph Search

Some Results of the EU Project FASTGRID

The EU FASTGRID project aimed at improving the REBCO conductor in order to enhance its economical attractiveness for the Superconducting Fault Current Limiter (SFCL). Two approaches were simultaneously investigated: i) the reduction of the tape length thro ...

IEEE Institute of Electrical and Electronics Engineers2022

FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1

Pierluigi Bruzzone, Jan Steggemann, Elena Graverini, Jean-Michel Sallese, Thomas Rizzo, Luca Rossi, Rui Ning Wang, Fabio Avino, Xavier Buffat, Tatiana Pieloni

We review the physics opportunities of the Future Circular Collider, covering its e(+)e(-), pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, ...

2019

FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2

Pierluigi Bruzzone, Jan Steggemann, Elena Graverini, Tatiana Pieloni, Jean-Michel Sallese, Mikhail Chapochnikov, Luca Rossi, Vincenzo D'Auria, Javier Barranco Garcia, Fabio Avino

In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-e ...

2019

HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4

Pierluigi Bruzzone, Jan Steggemann, Elena Graverini, Jean-Michel Sallese, Thomas Rizzo, Luca Rossi, Leonid Rivkin, Eva Maria Rodriguez Franco, Fabio Avino, Mikhail Chapochnikov

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider ...

2019

FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3

Pierluigi Bruzzone, Jan Steggemann, Jean-Michel Sallese, Elena Graverini, Tatiana Pieloni, Mikhail Chapochnikov, Luca Rossi, Javier Barranco Garcia, Claudia Tambasco, Fabio Avino

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider ...

2019

Pharmacological Activity Of Cb-103-An Oral Pan-Notch Inhibitor With A Novel Mode Of Action

Freddy Radtke, Manuel Bauer, Rajwinder Lehal, Maximilien Murone

Ferrata Storti Foundation2017

Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor with a novel mode of action

Freddy Radtke, Manuel Bauer, Rajwinder Lehal, Maximilien Murone

Oxford Univ Press2017

Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons

Patrick Aebischer, Manuel Bauer

Delta-like 1 (Dlk1), a member of the Delta/Notch protein family, is expressed in the mouse ventral midbrain (VM) as early as embryonic day 11.5 (E11.5) followed by exclusive expression in tyrosine 3-monooxygenase (TH) positive neurons from E12.5 onwards. T ...

Wiley-Blackwell2008

Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production

Patrick Aebischer, Manuel Bauer

Parkinson's disease (PD) is characterized by the progressive degeneration of the nigrostriatal dopaminergic system. Brain delivery of glial cell line-derived neurotrophic factor (GDNF) has been shown to protect and restore the dopaminergic pathway in vario ...

Wiley-Blackwell2005

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

Patrick Aebischer, Christophe Lo Bianco, Bernard Schneider, Manuel Bauer

Parkinson's disease (PD) is characterized by a progressive loss of midbrain dopamine neurons and the presence of cytoplasmic inclusions called Lewy bodies. Mutations in several genes including alpha-synuclein and parkin have been linked to familial PD. The ...

National Academy of Sciences2004