Publications de Dominique Pioletti

Causal associations between scapular morphology and shoulder condition estimated with Bayesian statistics

Dominique Pioletti, Alexandre Terrier, Philippe Büchler

Background and Objective: While there is a reported correlation between shoulder condition and scapular morphology, the precise impact of typical anatomical variables remains a subject of ongoing debate. This study aimed to evaluate this causal association ...

2025

"Heat of the Moment: The Overlooked Key to Cartilage Engineering''

Dominique Pioletti, Theofanis Stampoultzis

Articular cartilage's limited regenerative capacity is compounded by the overlooked thermomechanical factors critical to its function. Recent studies emphasize the importance of cartilage self-heating, arising predominantly from energy dissipation under ph ...

AMER CHEMICAL SOC2025

Combining systemic and local osteoporosis treatments: A longitudinal in vivo microCT study in ovariectomized rats

Dominique Pioletti

Introduction: Managing osteoporotic patients at immediate fracture risk is challenging, in part due to the slow and localized effects of anti-osteoporotic drugs. Combining systemic anti-osteoporotic therapies with local bone augmentation techniques offers ...

2025

Helmet material design for mitigating traumatic axonal injuries through AI-driven constitutive law enhancement

Dominique Pioletti, Pierre-Etienne Bourban, Naser Nasrollahzadeh Mamaghani, Vincent Marc Varanges

Sports helmets provide incomplete protection against brain injuries. Here we aim to improve helmet liner efficiency by employing a novel approach that optimizes their properties. By exploiting a finite element model that simulates head impacts, we develope ...

2025

Design of Customized Mouthguards with Superior Protection Using Digital-Based Technologies and Impact Tests

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Martin Broome

Background In contact sports, an impact on the jaw can generate destructive stress on the tooth-bone system. Mouthguards can be beneficial in reducing the injury risk by changing the dynamics of the trauma. The material properties of mouthguards and their ...

Springer2024

Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels

Dominique Pioletti, Peyman Karami, Lee Ann Laurent-Applegate

Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage r ...

MDPI2024

Banked Primary Progenitor Cells for Allogeneic Intervertebral Disc (IVD) Therapy: Preclinical Qualification and Functional Optimization within a Cell Spheroid Formulation Process

Dominique Pioletti

Background/Objectives: Biological products are emerging as therapeutic management options for intervertebral disc (IVD) degenerative affections and lower back pain. Autologous and allogeneic cell therapy protocols have been clinically implemented for IVD r ...

2024

Impact of Molecular Dynamics of Polyrotaxanes on Chondrocytes in Double-Network Supramolecular Hydrogels under Physiological Thermomechanical Stimulation

Dominique Pioletti, Theofanis Stampoultzis, Yanheng Guo, Vijay Kumar Rana

Hyaline cartilage, a soft tissue enriched with a dynamic extracellular matrix, manifests as a supramolecular system within load-bearing joints. At the same time, the challenge of cartilage repair through tissue engineering lies in replicating intricate cel ...

American Chemical Society2024

An Adhesive Hydrogel Technology for Enhanced Cartilage Repair: A Preliminary Proof of Concept

Dominique Pioletti

Knee cartilage has limited natural healing capacity, complicating the development of effective treatment plans. Current non-cell-based therapies (e.g., microfracture) result in poor repair cartilage mechanical properties, low durability, and suboptimal tis ...

2024

Customized modular multi-material mouthguard and method of making the same

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Martin Broome

There is described a mouthguard comprising an externally exposed impact protective region defined by a first material property and configured to cover a front tooth, an internally exposed occlusional cushioning region defined by a second material property ...

2024