Publications de Thierry Sengstag

Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

Darlene Goldstein, Mauro Delorenzi, Thierry Sengstag, Benjamin Haibe-Kains

Introduction Breast cancer subtyping and prognosis have been studied extensively by gene expression profiling, resulting in disparate signatures with little overlap in their constituent genes. Although a previous study demonstrated a prognostic concordance ...

2008

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

Darlene Goldstein, Mauro Delorenzi, Thierry Sengstag

To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) a ...

Oxford University Press2007

Regional and cellular gene expression changes in human Huntington's disease brain

Darlene Goldstein, Mauro Delorenzi, Doris Chau Voo Thu, Thierry Sengstag

Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been available. To elucidate the molecular phenotype of HD on a genome- ...

Oxford University Press2006

On the modeling of reactivity initiated accidents in light water reactor cores containing high-burnup fuel

Thierry Sengstag

EPFL2001