Personne
Nico Westerhof
Publications associées (28)
Contribution of the Arterial System and the Heart to Blood Pressure during Normal Aging - A Simulation Study
Nikolaos Stergiopoulos, Elira Maksuti, Nico Westerhof
During aging, systolic blood pressure continuously increases over time, whereas diastolic pressure first increases and then slightly decreases after middle age. These pressure changes are usually explained by changes of the arterial system alone (increase ...
Public Library of Science2016Systolic Hypertension Mechanisms: Effect of Global and Local Proximal Aorta Stiffening on Pulse Pressure
Nikolaos Stergiopoulos, Philippe Reymond, Nico Westerhof
Decrease in arterial compliance leads to an increased pulse pressure, as explained by the Windkessel effect. Pressure waveform is the sum of a forward running and a backward running or reflected pressure wave. When the arterial system stiffens, as a result ...
Springer US2012RC time constant of single lung equals that of both lungs together: a study in chronic thromboembolic pulmonary hypertension
Nikolaos Stergiopoulos, Nico Westerhof
The product of resistance, R, and compliance, C (RC time), of the entire pulmonary circulation is constant. It is unknown if this constancy holds for individual lungs. We determined R and C in individual lungs in chronic thromboembolic pulmonary hypertensi ...
2009Left ventricular hypertrophy induced by reduced aortic compliance
Nikolaos Stergiopoulos, Nico Westerhof
It was the aim of this study to investigate the long- term effects of reduced aortic compliance on cardiovascular hemodynamics and cardiac remodeling. ...
2009Individualization of transfer function in estimation of central aortic pressure from the peripheral pulse is not required in patients at rest
Nikolaos Stergiopoulos, Nico Westerhof
Central aortic pressure gives better insight into ventriculo-arterial coupling and better prognosis of cardiovascular complications than peripheral pressures. Therefore transfer functions (TF), reconstructing aortic pressure from peripheral pressures, are ...
2008Three- and four-element Windkessel models: assessment of their fitting performance in a large cohort of healthy middle-aged individuals
Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof
Lumped-parameter models are used to estimate the global arterial properties by fitting the model to measured (aortic) pressure and flow. Different model configurations coexist, and it is still an open question as to which model optimally reflects the arter ...
2008Arterial pressure transfer characteristics: effects of travel time
Nikolaos Stergiopoulos, Nico Westerhof
We investigated the quantitative contribution of all local conduit arterial, blood, and distal load properties to the pressure transfer function from brachial artery to aorta. The model was based on anatomical data, Young's modulus, wall viscosity, blood v ...
2006Nonlinear isochrones in murine left ventricular pressure-volume loops: how well does the time-varying elastance concept hold?
Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof
The linear time-varying elastance theory is frequently used to describe the change in ventricular stiffness during the cardiac cycle. The concept assumes that all isochrones (i.e., curves that connect pressure-volume data occurring at the same time) are li ...
2005Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice
Nikolaos Stergiopoulos, Patrick Segers, Nico Westerhof
Global assessment of both cardiac and arterial function is important for a meaningful interpretation of pathophysiological changes in animal models of cardiovascular disease. We simultaneously acquired left ventricular (LV) and aortic pressure and LV volum ...
2004Hemodynamics induced after acute reduction of proximal thoracic aorta compliance
Nikolaos Stergiopoulos, Nico Westerhof
to investigate the affect of reduced aortic compliance on cardiovascular hemodynamics. ...
2003