Publications de Mathieu Chastellain

INJECTABLE SUPERPARAMAGNETIC NANOPARTICLES FOR TREATMENT BY HYPERTHERMIA AND USE FOR FORMING AN HYPERTHERMIC IMPLANT

Heinrich Hofmann, Alke Fink, Mathieu Chastellain, Olivier Jordan

The injectable formulation for treatment by hyperthermia comprises a liquid carrier and heat-generating superparamagnetic iron oxide nanoparticles having a mean diameter not greater than 20 nm. Said injectable formulation is able to form in-situ a hyperthe ...

2006

Plastic Micropump with ferrofluidic actuation

Martinus Gijs, Heinrich Hofmann, Virendra Kumar Parashar, Alke Fink, Christophe Yamahata, Mathieu Chastellain

Institute of Electrical and Electronics Engineers2005

Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep

Heinrich Hofmann, Alke Fink, Benedikt Steitz, Mathieu Chastellain

A superparamagnetic iron oxide nanoparticle, coated with polyvinyl alcohol, (PVA-SPION) and its fluorescently functionalized analogue (amino-PVA-Cy3.5-SPION) were compared in vivo as proof of principle for future use in magnetic drug targeting in inflammat ...

2005

Methodology description for detection of cellular uptake of PVA coated superparamagnetic iron oxide nanoparticles (SPION) in synovial cells of sheep

Heinrich Hofmann, Alke Fink, Mathieu Chastellain

The detection of superparamagnetic iron oxide nanoparticles (SPION) in synoviocytes is reported. Synoviocytes were incubated for 2, 12, 24 and 48 h with 1.5 mg/ml of PVA coated SPION under the influence of magnets (12 h). Particles were well tolerated by t ...

2005

Development of biocompatible functionalized superparamagnetic iron oxide nanoparticles for human cancer cell uptake and intracellular delivery

Heinrich Hofmann, Alke Fink, Alessio Ferrari, Mathieu Chastellain

2005

Particle size investigations of a multistep synthesis of PVA coated superparamagnetic nanoparticles

Heinrich Hofmann, Alke Fink, Mathieu Chastellain

Nanoscaled particles showing superparamagnetic behavior have been intensively studied in the past years for various applications. Nevertheless, the lack of well-defined particles remains an important problem. One of the major challenges is still the large- ...

2004

Nanoscale superparamagnetic composite particles for biomedical applications

Mathieu Chastellain

The present thesis report deals about the material scientists contribution to the interdisciplinary European project "MAGNANOMED" involving people having very different backgrounds (physicist, chemists, biochemists, veterinary surgeons, ...). The work carr ...

EPFL2004

Superparamagnetic iron oxide Nanoparticles for biomedical application: a focus on PVA as a coating

Heinrich Hofmann, Alke Fink, Mathieu Chastellain

2003