Publications de Philippe Pittet

SciFi detector and associated method for real-time determination of profile and output factor for small fields in stereotactic radiotherapy

Guido Haefeli, Frédéric Blanc, Plamen Hristov Hopchev, Philippe Pittet

Purpose For determining small-field profile and output factor during stereotactic radiotherapy quality assurance (QA) procedures, we propose a novel system based on the scintillating fiber (SciFi) detector with output image acquisition and processing to al ...

WILEY2020

Cadherins establish mechano-resistant junctions between fibrogenic fibroblasts

Philippe Pittet

During wound healing and in a variety of fibrocontractive diseases, fibroblasts differentiate into contractile myofibroblasts by acquiring stress fibers and by expressing α-smooth muscle actin (α-SMA). Myofibroblasts of wound granulation tissue, in contras ...

EPFL2008

Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds

Andrzej Kulik, Jean-Jacques Meister, Boris Hinz, Kyumin Lee, Philippe Pittet

We have previously shown that the switch from N-cadherin to OB-cadherin expression increases intercellular adhesion between fibroblasts during their transition from a migratory to a fibrogenic phenotype. Using atomic force microscopy we here show that part ...

2008

Ob-cadherin establishes mechano-resistant junctions between myofibroblasts

Andrzej Kulik, Jean-Jacques Meister, Boris Hinz, Kyumin Lee, Philippe Pittet

2007

Evidence for signaling via gap junctions from smooth muscle to endothelial cells in rat mesenteric arteries: possible implication of a second messenger

Jean-Jacques Meister, Jean-Louis Bény, Roger Sauser, Michèle Koenigsberger, Philippe Pittet, Mathieu Lamboley

We investigated heterocellular communication in rat mesenteric arterial strips at the cellular level using confocal microscopy. To visualize Ca(2+) changes in different cell populations, smooth muscle cells (SMCs) were loaded with Fluo-4 and endothelial ce ...

Elsevier2005