Thomas Lehnert

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Publications associées (52)

Anin vivomicrofluidic study of bacterial transit inC. elegansnematodes

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Hüseyin Baris Atakan, Vittorio Viri

Caenorhabditis elegans(C. elegans) constitutes an important model organism for use in nutrition and aging studies. We report a novel method for studying the dynamics ofEscherichia coli(E. coli) bacterial transit through the worms' intestine. A microfluidic ...

2020

Microfluidic system for Caenorhabditis elegans culture and oxygen consumption rate measurements

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Roger Philippe Krenger

Mitochondrial respiration is a key signature for the assessment of mitochondrial functioning and mitochondrial dysfunction is related to many diseases including metabolic syndrome and aging-associated conditions. Here, we present a microfluidic Caenorhabdi ...

ROYAL SOC CHEMISTRY2020

Dynamic microfluidic nanocalorimetry system for measuring Caenorhabditis elegans metabolic heat

Martinus Gijs, Thomas Lehnert, Roger Philippe Krenger

2018

Integrated Microfluidic Device for Drug Studies of Early C. Elegans Embryogenesis

Martinus Gijs, Pierre Gönczy, Thomas Lehnert, Matteo Cornaglia, Li Dong, Radek Jankele

2018

Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Li Dong, Govindan Narayanan Krishnamani, Jingwei Zhang

2018

8-Channel Single Embryo Pipette For Accurate C-Elegans Bioassays

Martinus Gijs, Thomas Lehnert, Li Dong, Jingwei Zhang

The nematode Caenorhabditis elegans (C. elegans) is a powerful model organism for addressing fundamental biological questions related to human disease and aging. Accurate control of the number of worms is a primary step for quantitative biological or bioch ...

IEEE2018

An Integrated Microfluidic Device For C-Elegans Early Embryogenesis Studies And Drug Assays

Martinus Gijs, Pierre Gönczy, Thomas Lehnert, Matteo Cornaglia, Li Dong, Radek Jankele, Jingwei Zhang

The Caenorhabditis elegans embryo is a widely used model for the functional analysis of dynamic cellular processes, such as chromosome segregation, cytokinesis or lineage analysis. However, the conventional embryo preparation method that relies on manually ...

Ieee2017

Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia

In a typical high-throughput drug screening (HTS) process, up to millions of chemical compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit a robust dose-response, as evidenced for example by a fluorescence signal. I ...

Royal Soc Chemistry2017

C. Elegans Immobilization Using Deformable Microfluidics For In Vivo Studies Of Early Embryogenesis And Intestinal Microbiota

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Li Dong, Xiaopeng Huang, Jingwei Zhang

The genome of the nematode Caenorhabditis elegans shows far-reaching similarities to that of humans. C. elegans is therefore considered as a powerful model organism in biological research related to humans, for instance for the study of human diseases. Suc ...

Ieee2017

Track C. Biomedical Instrumentation & Micro and Nano Systems

Johan Auwerx, Matteo Cornaglia, Martinus Gijs, Thomas Lehnert, Laurent Mouchiroud, Vincenzo Sorrentino, Alexis Pierre Henri Marette, Virginija Jovaisaite, Govindan Narayanan Krishnamani, Shreya Narasimhan

De Gruyter2016

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Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Li Dong, Govindan Narayanan Krishnamani, Jingwei Zhang

2018

Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia

Royal Soc Chemistry2017

C. Elegans Immobilization Using Deformable Microfluidics For In Vivo Studies Of Early Embryogenesis And Intestinal Microbiota

Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Li Dong, Xiaopeng Huang, Jingwei Zhang

Ieee2017

Track C. Biomedical Instrumentation & Micro and Nano Systems

De Gruyter2016