Personne

Christoph Herwig

Publications associées (9)

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A multi-TeV muon collider offers a spectacular opportunity in the direct exploration of the energy frontier. Offering a combination of unprecedented energy collisions in a comparatively clean leptonic environment, a high energy muon collider has the unique ...

Iop Publishing Ltd2024

Generally applicable fed-batch culture concept based on the detection of metabolic state by on-line balancing

Urs von Stockar, Ian William Marison, Christoph Herwig, Bernhard Walker

In many microorganisms, flux limitations in oxidative metab. lead to the formation of overflow metabolites even under fully aerobic conditions. This can be avoided if the specific growth rate is controlled at a low enough value. This is usually accomplishe ...

2003

A multitude of metabolic regulations occur in yeast, particularly under dynamic process conditions, such as under sudden glucose excess. However, quantification of regulations and classification of yeast strains under these conditions have yet to be elucid ...

2003

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A review, with refs. This contribution analyzes the position of biochem. engineering in general and bioprocess engineering particularly in the force fields between fundamental science and applications, and between academia and industry. By using culture te ...

2003

Quantitative analysis of the oxidative metabolism in HXK2- and REG1-deletion mutants of Saccharomyces cerevisiae

Urs von Stockar, Christoph Herwig

Deletion mutants with either deletion of HXK2 and REG1 of the wild-type strain Saccharomyces cerevisiae CEN.PK113-7D were quant. analyzed for the impact on carbon catabolite repression and the short-term effect of the oxidative metab. Therefore, continuous ...

2002

A small metabolic flux model to identify transient metabolic regulations in Saccharomyces cerevisiae

Urs von Stockar, Christoph Herwig

The understanding of dynamic metabolic regulations is important for physiol. studies and strain characterization tasks. The present study combined transient expts. with online metabolic flux anal. (MFA) in order to quantify metabolic regulations, namely ca ...

2002

Quantitative analysis of the impact of HXK2 and REG1 deletion in Saccharomyces cerevisiae on invertase expression and respiration

Urs von Stockar, Ian William Marison, Christoph Herwig

In Saccharomyces cerevisiae, the genes HXK2 and REG1 are believed to play a central role in carbon catabolite repression, acting on multiple pathways in the central metab. The present study aimed at quantifying the effect of deletion of genes HXK2 or REG1, ...

2002

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A method for the online calcn. of conversion rates and yield coeffs. under dynamic process conditions was developed. The method is based on cumulated mass balances using a moving av. method. Elemental balances were used to test the measured cumulated quant ...

2001

Quantitative analysis of the regulation scheme of invertase expression in Saccharomyces cerevisiae

Urs von Stockar, Ian William Marison, Christoph Herwig

In Saccharomyces cerevisiae, the expression of invertase, which is the hydrolyzing enzyme of sucrose, is controlled by the presence of monosaccharides, such as glucose and fructose, and referred to as carbon catabolite repression. To date, efforts have bee ...

2001