Publications de Sophie Bohnet | EPFL Graph Search

Comparative maps of motion and assembly of filamentous actin and myosin II in migrating cells

Jean-Jacques Meister, Alexander Verkhovskiy, Sébastien Schaub, Sophie Bohnet

To understand the mechanism of cell migration, one needs to know how the parts of the motile machinery of the cell are assembled and how they move with respect to each other. Actin and myosin II are thought to be the major structural and force-generating c ...

American Society for Cell Biology2007

Dynamics of actin and myosin II during cell polarization and directional locomotion

Sophie Bohnet

Crawling cell motility is characteristic of most animal cells and is involved in many important biological processes such as embryogenesis, immune response, and wound healing. It involves several steps: protrusion (dynamic surface extension) at the front o ...

EPFL2006

Tracking retrograde flow in keratocytes: news from the front

Jean-Jacques Meister, Sophie Bohnet, Alexander Verkhovskiy

Actin assembly at the leading edge of the cell is believed to drive protrusion, whereas membrane resistance and contractile forces result in retrograde flow of the assembled actin network away from the edge. Thus, cell motion and shape changes are expected ...

American Society for Cell Biology2005

Weak force stalls protrusion at the leading edge of the lamellipodium

Jean-Jacques Meister, Sophie Bohnet, Alexander Verkhovskiy, Alex Mogilner

Protrusion, the first step of cell migration, is driven by actin polymerization coupled to adhesion at the cell's leading edge. Polymerization and adhesive forces have been estimated, but the net protrusion force has not been measured accurately. We arrest ...

Elsevier2005